摘要
钽具有'亲生物'金属之称,具有极佳的生物惰性和生物相容性。纯钽应用于骨科医疗至今已经80多年。由于纯钽与骨组织弹性模量相差较大,不利于骨结合,然而多孔钽却在提供力学强度的同时可减少应力遮挡,有利于应力传导,便于骨骼塑形,同时具有优良的骨诱导性,广泛应用于骨科领域,并取得了理想疗效。但是由于人体的差异性、骨缺损部位形态的随机性,如骨肿瘤患者、骨畸形患者等,标准化多孔钽已经不能满足患者个性化治疗要求。从临床医学发展趋势看,最好的治疗方法应该是个性化治疗,最好的植入体应该是个性化植入体。未来需要解决钽粉原材料及价格、专用设备及工艺、3D打印工艺与传统工艺的差异、多组分梯度打印等方面的问题。
Tantalum,known as'pro-biometal',has excellent bio-inertness and bio-compatibility.Pure tantalum has been used in orthopedics for longer than 80 years.But pure tantalum has little in common with bone tissue in the elastic modulus and is not conducive to osseointegration,while,porous tantalum can not only provide mechanical strength but also reduce stress occlusion,facilitate stress conduction,promote bone shaping,and has excellent osteoinduction,which is widely used in orthopedics and has achieved ideal outcomes.However,due to great diversities in human body and randomness of bone defect sites,such as patients with bone tumors and those with bone deformities,standardized porous tantalum is unable to meet the patients’individualized treatment requirements.From the perspective of clinical development,the optional treatment should be individualized,and the best implant should also be individualized.In the future,we need to focus on the following problems,tantalum powder and its price,special equipment and manufacturing process,differences between 3 D and traditional manufacure,and multicomponent gradients and others.
作者
杨柳
王富友
YANG Liu;WANG Fuyou(Center for Joint Surgery,First Affiliated Hospital,Army Medical University(Third Military Medical University),Chongqing,400038,China)
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2019年第19期1859-1866,共8页
Journal of Third Military Medical University
基金
国家重点研发计划(2016YFB1101400)~~
关键词
多孔钽
3D打印
临床应用
个性化治疗
porous tantalum
3D printing
clinical application
individualized treatment
