摘要
目的:研究内皮素(ET-1)、P-选择素、肌钙蛋白I(CTn1)在急性心肌梗死(AMI)和不稳定性心绞痛(UA)中的意义。方法:用放射免疫法测ET-1,流式细胞术测定P-选择素,Access化学发光法测CTnI,共检测23例AMI患者、21例UA患者及28例健康对照者。结果:AMI组的ET-1、P-选择素、CTnI值均显著高于对照组(P<0.05～0.005);UA组的ET-1、P-选择素显著高于对照组(P<0.05);UA组的CTnI与对照组差异无显著性(P>0.05);UA组的P-选择素、CTnI显著低于AMI组(P<0.05)。多元回归分析发现P-选择素与CTnI相关,相关系数r=0.404,P<0.01。结论:ET-1、P-选择素是检测血栓前状态的敏感指标。
Objective: To explored the relationship among endothelin-1, P-selection and troponin I in acute myocardial infarction (AMI) and unstable angina(UA). Methods: Plasma level of endothelin-1 was analyzed by radioimmunoassay, the expression of P-selection by flow cytometery tecnique and troponin I by paramagnetic-partile chemiluminescent immunoassay in 23 cases with AMI, 21 UA and 28 healthy controls. Results: Plasma levels of endothelin-1 and troponin I were significantly higher in patients with AMI than in controls(P<0.05). The expression of P-selection was significantly higher in patients AMI than in con trols(P< 0.05). Plasma levels of endothelin-1 and expression of P-selection were significantly higher in patients with UA than controls(P<0.05). There was an incresed trend of troponin I in patients with UA in contrast to controls, but without statistical significance(P>0.05). As compared with UA, plasma levels of troponin I and expression of P-selection were significantly elevated in patients with AMI(P<0.05). No significant difference was observed between AMI and UA in plasma level of endothelin-1. Multivariate regression analysis revealed that P-selection was significantly associated with AMI and UA compared with plasma level of troponin I(r=0.404, P<0.01). Conclusion: Plasma levels of endothelin-1 and P-selection and troponin I were sensitive markers as prembolic status.
出处
《血栓与止血学》
2002年第3期105-106,共2页
Chinese Journal of Thrombosis and Hemostasis
