摘要
ＣＴ扫描技术的应用，大大提高了对脑瘤定位诊断的准确性。但ＣＴ检查能否同时判断肿瘤的大致分级、ＤＮＡ含量（ＤＩ）、细胞增殖指数（ＰＩ）及预后情况，从而更好地为临床提供诊断和治疗依据，这是目前需要探索的一个重要课题。本文对６０例星形细胞瘤的ＣＴ值与其病理分级、ＤＮＡ含量、ＰＩ值以及术后生存期进行了初步研究，结果显示：（１）ＣＴ值与病理分级密切相关，即按病理为Ⅰ、Ⅱ和Ⅲ－Ⅳ级的分组顺序，各组的ＣＴ值逐渐增大；（２）ＣＴ值与ＤＮＡ含量和细胞增殖指数呈正相关关系。即按上述病理分级，各组的ＤＩ和ＰＩ值均随ＣＴ强化（或非强化）值的增大而逐渐增大；（３）ＣＴ值与其预后的关系十分密切，即随ＣＴ值的增高，术后生存时间缩短。在ＣＴ非强化值分别为２９３１±１１９、３９３１±１９１、４６１０±１２２和ＣＴ强化值分别为４０２５±０６０、４４７７±０９９、６５６０±１４６的３组中，其术后存活时间分别为７２、５５和２６个月，呈负相关关系。本研究结果表明，ＣＴ值可以作为推测星形细胞瘤的分级、ＤＮＡ含量水平、细胞增殖程度及术前对预后的综合判断依据，对提高脑瘤的临床诊治水平具有重要参考价值。
As an advanced method of examination, CT diagnosis of brain tumors is more accurate for localization. Yet, whether CT examination could reflex the pathological grade, DNA contents (DI), proliferation indices(PI) as well as prognosis of the patients of brain tumors so as to set more scientific basis for clinical diagnosis and treatment is still a very important problem to be further explored. In this paper, the relationship between CT value and DI, PI as well as postoperative survival was studied in 60 cases of astrocytomas in brain. The results showed that CT values were positively correlated with DI and PI. On the other hand, the higher the CT value, the poorer the prognosis. There were significant differences in CT value, DI, PI and postoperative survival among the following three pathological grade groups. The corresponding CT values before/after contrast enhancement for grade Ⅰ, Ⅱ and Ⅲ-Ⅳ groups were 29 31±1 19/40 25±0 60, 39 31±1 91/44 77±0 99 and 46 10±1 22/65 60±1 46. The DI and PI and postoperative survival time were 1 17±0 17, 1 21±0 05, 1 31±0 13; 36 00±2 57, 39 88±2 88, 46 57±4 36 and 72, 55, 26 months for grade Ⅰ, Ⅱ and Ⅲ-Ⅳ groups, respectively. There fore, CT examination of brain tumer may perfectly reflex its nature and prognosis, giving an important mark in clinical practice.
出处
《中国体视学与图像分析》
1997年第1期46-48,共3页
Chinese Journal of Stereology and Image Analysis
