摘要
本文应用实验性肝坏死大白鼠研究人胎肝细胞生长刺激物质(HSS)、抗肿瘤坏死因子(TNF)的作用及其机理。结果显示HSS能对抗D－氨基半乳糖、内毒素引起的肿瘤坏死因子水平升高,对抗肝糖原、血糖浓度的降低,明显提高实验性肝坏死大白鼠的存活率。实验大鼠血清中葡萄糖醛酸苷酶及肝细胞内酸性磷酸酶活性一致性低下,提示HSS可以稳定溶酶体并对抗肿瘤坏死因子对溶酶体的激活作用。
The effects of HSS in experimental liver necrosis in rat and the mechanism of its anti-TNF effect in TNF-induced liver necrosis have been studied in this paper . The results showed that HSS could improve the survival rate of rats with experimental liver necrosis, and it also could antagonize the effects which were induced by D-galactosamine and endotoxin. including the higher level of TNF and the lower serum-glucose level, and it also can inhibit the activation of B-G enzyme and ACP enzyme. These suggested that HSS could stabilize lysosome and inhibit the activating effects by TNF on lysosome.
出处
《重庆医药》
CSCD
1991年第6期321-323,共3页
