摘要
本文用小扁豆凝集素(LCA)亲和交叉免疫电泳法检测血清岩藻糖化甲胎蛋白(Fuc-AFP)共167例,结果进一步证明AFP岩藻糖化指数(Fucl)测定对原发性肝癌(PHC)(72例)诊断敏感性及特异性分别为84.7%和89.5%;在AFP阴性或低滴度阳性PHC病例中的阳性率达76.6%.FucI与AFP联合检测使诊断PHC的阳性率上升为90.3%.5例PHC手术切除或化疗后FucI随病情好转恶化而下降或上升.
By means of crossed immuno-affinoelectrophresis,serum fucosylated AFP(Fuc AFP)was determined in 167 cases, including primary hepatic carcinoma (PHC) (72 cases), various liver diseases(54 cases), other gastrointestinal tumors (4 cases),and healthy controls (37 cases) .The results showed that serum fucosylation index of AFP (FucI) was significantly higher in PHC than in controls and other diseases (P<0.001). As markers,FucI was useful in the diagnosis of PHC with sensitivity of 84.7% and specificity of 89.5%.The diagnostic positivity was 76.7% in PHC patients with normal or low producing AFP.Through combination of FucI and AFP assa-y, the diagnostic positivity was raised to 90.3%.Marked fall in both FucI and AFP levels were noted in 5 patients with PHC after surgical resection or chemotherapy. In correlation with Edmondson classification of 17 patients with hepatoma, it showed that the serum levels of FucI was higher in well differentiated tumors than in poorly differentiated ones
出处
《重庆医科大学学报》
CAS
CSCD
1991年第2期96-101,共6页
Journal of Chongqing Medical University
