摘要
蛋白质酪氨酸在一系列细胞活动的信号转导途径中起着重要的作用。在包括癌症和其他许多疾病的治疗研究中 ,酪氨酸激酶都是研究的目标和对象。本文综述了近年来酪氨酸激酶抑制剂的研究进展 。
Protein tyrosine kinases play an important role in signal transduction pathways in regulating a number of cellular functions. Tyrosine kinases are attractive as targets in the research of therapeutic agents, not only against cancer, but also against many other diseases. The progress in tyrosine kinase inhibitor has been reviewed, including the chemical structures and the pharmacophore models.
出处
《化学进展》
SCIE
CAS
CSCD
2002年第5期355-359,共5页
Progress in Chemistry
