摘要
Objectives Because the endothelium is a major target for inflammatory c ytokine s, we investigated whether elevated interleukin (IL)-10 serum levels are associ ated with improved endothelial vasoreactivity in patients with coronary artery d isease (CAD). Background Chronic inflammation plays a pivotal role in the progre ssion of atherosclerosis. Interleukin-10 is an anti-inflammatory cytokine that exerts important protective effects on atherosclerotic lesion development in ex perimental animals. Methods Vasoreactivity was assessed in 65 male patients with documented CAD by measuring endothelium-dependent (acetylcholine <<ACh>> 10 to 5 0 μg/min) and endothelium-independent (sodium nitroprusside <<SNP>> 2 to 8 μg/m in) forearm blood flow (FBF) responses using venous occlusion plethysmography. R esults Serum levels of IL-10 were significantly correlated with ACh-induced FB F responses (r=0.31, p< 0.02), but not with SNP responses. Importantly, if IL-1 0 serum levels were increased in patients with elevated C-reactive protein (CRP ) levels, no impairment of ACh-stimulated FBF response was observed. On multiva riate analysis, including low-density lipoprotein cholesterol, smoking, hyperte nsion, diabetes, clinical status of the patients, and statin and/or angiotensin -converting enzyme inhibitor treatment, only IL-10 (p< 0.02) and CRP serum lev els (p< 0.02) were significant independent predictors of ACh-induced FBF respon ses. Conclusions Thus, increased IL-10 serum levels are associated with improve d systemic endothelial vasoreactivity in patients with elevated CRP serum levels , demonstrating that the balance between pro-and anti-inflammatory mediators i s a major determinant of endothelial function in patients with CAD.
Objectives Because the endothelium is a major target for inflammatory c ytokine s, we investigated whether elevated interleukin (IL)-10 serum levels are associ ated with improved endothelial vasoreactivity in patients with coronary artery d isease (CAD). Background Chronic inflammation plays a pivotal role in the progre ssion of atherosclerosis. Interleukin-10 is an anti-inflammatory cytokine that exerts important protective effects on atherosclerotic lesion development in ex perimental animals. Methods Vasoreactivity was assessed in 65 male patients with documented CAD by measuring endothelium-dependent (acetylcholine <<ACh>> 10 to 5 0 μg/min) and endothelium-independent (sodium nitroprusside <<SNP>> 2 to 8 μg/m in) forearm blood flow (FBF) responses using venous occlusion plethysmography. R esults Serum levels of IL-10 were significantly correlated with ACh-induced FB F responses (r=0.31, p< 0.02), but not with SNP responses. Importantly, if IL-1 0 serum levels were increased in patients with elevated C-reactive protein (CRP ) levels, no impairment of ACh-stimulated FBF response was observed. On multiva riate analysis, including low-density lipoprotein cholesterol, smoking, hyperte nsion, diabetes, clinical status of the patients, and statin and/or angiotensin -converting enzyme inhibitor treatment, only IL-10 (p< 0.02) and CRP serum lev els (p< 0.02) were significant independent predictors of ACh-induced FBF respon ses. Conclusions Thus, increased IL-10 serum levels are associated with improve d systemic endothelial vasoreactivity in patients with elevated CRP serum levels , demonstrating that the balance between pro-and anti-inflammatory mediators i s a major determinant of endothelial function in patients with CAD.
