摘要
Objective: To quantify visual discrimination, spacem otion, and objectform perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD). Methods: Th e authors used a crosssectional study to compare three demented groups matched for overall dementia severity (PDD: n=24; DLB: n=20; AD: n=23) and two age, s ex, and educationmatched control groups (PD: n=24, normal controls [NC]: n =2 5). Results: Visual perception was globally more impaired in PDD than in nondeme nted controls (NC, PD), but was not different from DLB. Compared to AD, PDD pati ents tended to perform worse in all perceptual scores. Visual perception of pati ents with PDD/DLB and visual hallucinations was significantly worse than in pati ents without hallucinations. Conclusions: Parkinson disease dementia (PDD) is as sociated with profound visuoperceptual impairments similar to dementia with Lewy bodies (DLB) but different from Alzheimer disease. These findings are consisten t with previous neuroimaging studies reporting hypoactivity in cortical areas in volved in visual processing in PDD and DLB.
Objective: To quantify visual discrimination, spacem otion, and objectform perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD). Methods: Th e authors used a crosssectional study to compare three demented groups matched for overall dementia severity (PDD: n=24; DLB: n=20; AD: n=23) and two age, s ex, and educationmatched control groups (PD: n=24, normal controls [NC]: n =2 5). Results: Visual perception was globally more impaired in PDD than in nondeme nted controls (NC, PD), but was not different from DLB. Compared to AD, PDD pati ents tended to perform worse in all perceptual scores. Visual perception of pati ents with PDD/DLB and visual hallucinations was significantly worse than in pati ents without hallucinations. Conclusions: Parkinson disease dementia (PDD) is as sociated with profound visuoperceptual impairments similar to dementia with Lewy bodies (DLB) but different from Alzheimer disease. These findings are consisten t with previous neuroimaging studies reporting hypoactivity in cortical areas in volved in visual processing in PDD and DLB.
