摘要
Background:Phototherapy is already established as an effective mode of therapy in vitiligo.An evidence-based study was carried out of the effect of narrow-band(311 nm)ultraviolet-B(NB-UV-B)radiation in 66 surgically treated patients with recalcitrant vitiligo in whom autologous mini-punch grafting was deployed.Methods:A total of 2613 grafts were placed over 108 lesions on 17 regions in 66 individuals(39 females and 27 males)with stable,refractory vitiligo.The age range was 21-48 years.Post surgically,they were exposed to a suberythemal dose of NB-UV-B(311 nm).Different parameters of surgical repigmentation were documented.Results:Successful repigmentation was achieved in 57(86.36%)cases.The appearance of repigmentation(AOR)time in different regions varied between 14 and 32 days,with an overall average of approximately 20.6 days.Maximum pigment spread(MPS)-reached 12 mm with an average of 6.5 mm.The relationship between the donor graft area and area of surgical repigmentation was also calculated.Cobblestoning was the most common(31.8%)complication,but improved with time and/or interference.Conclusions:Punch grafting in combination with phototherapy(NB-UV-B,311 nm)was found to be an easy,safe,inexpensive,and effective method of repigmenting static and stubborn vitiligo.Different facets of punch grafting-induced and phototherapy-aided surgical repigmentation were taken into consideration.The area of repigmentation,MPS,and relationship between the donor graft area and area of surgical repigmentation were documented.
Background:Phototherapy is already established as an effective mode of therapy in vitiligo.An evidence-based study was carried out of the effect of narrow-band(311 nm)ultraviolet-B(NB-UV-B)radiation in 66 surgically treated patients with recalcitrant vitiligo in whom autologous mini-punch grafting was deployed.Methods:A total of 2613 grafts were placed over 108 lesions on 17 regions in 66 individuals(39 females and 27 males)with stable,refractory vitiligo.The age range was 21-48 years.Post surgically,they were exposed to a suberythemal dose of NB-UV-B(311 nm).Different parameters of surgical repigmentation were documented.Results:Successful repigmentation was achieved in 57(86.36%)cases.The appearance of repigmentation(AOR)time in different regions varied between 14 and 32 days,with an overall average of approximately 20.6 days.Maximum pigment spread(MPS)-reached 12 mm with an average of 6.5 mm.The relationship between the donor graft area and area of surgical repigmentation was also calculated.Cobblestoning was the most common(31.8%)complication,but improved with time and/or interference.Conclusions:Punch grafting in combination with phototherapy(NB-UV-B,311 nm)was found to be an easy,safe,inexpensive,and effective method of repigmenting static and stubborn vitiligo.Different facets of punch grafting-induced and phototherapy-aided surgical repigmentation were taken into consideration.The area of repigmentation,MPS,and relationship between the donor graft area and area of surgical repigmentation were documented.
