摘要
Background. The role of oxidative stress has not been fully understood in the aetiopathogenesis of vitiligo in different studies. Aim. We aimed to investigat e the role of the oxidative stress in the pathogenesis of vitiligo. Methods. In this study, we examined levels of superoxide dismutase, glutathione peroxidase, malondialdehyde and nitric oxide in tissue of 25 patients with generalized vitil igo and 25 healthy controls. Results. Our results revealed that levels of supero xide dismutase, glutathione peroxidase and malondialdehyde in tissue were signif icantly increased in patientswith generalized vitiligo (P < 0.05). However, ther e was no statistically significantly difference between two groups at tissue lev el of nitric oxide (P > 0.05). Conclusion. Our results demonstrate the presence of an imbalance in the oxidant-antioxidant system in vitiligo at tissue level and provide further support for a free radical-mediated damage as an initial p athogenic event in melanocyte degeneration in vitiligo.
Background. The role of oxidative stress has not been fully understood in the aetiopathogenesis of vitiligo in different studies. Aim. We aimed to investigat e the role of the oxidative stress in the pathogenesis of vitiligo. Methods. In this study, we examined levels of superoxide dismutase, glutathione peroxidase, malondialdehyde and nitric oxide in tissue of 25 patients with generalized vitil igo and 25 healthy controls. Results. Our results revealed that levels of supero xide dismutase, glutathione peroxidase and malondialdehyde in tissue were signif icantly increased in patientswith generalized vitiligo (P < 0.05). However, ther e was no statistically significantly difference between two groups at tissue lev el of nitric oxide (P > 0.05). Conclusion. Our results demonstrate the presence of an imbalance in the oxidant-antioxidant system in vitiligo at tissue level and provide further support for a free radical-mediated damage as an initial p athogenic event in melanocyte degeneration in vitiligo.
