摘要
Placental site trophoblastic tumor (PSTT) is a rare variant of gestational tro phoblastic disease that has been re-described during the 1970s. The patients’a ge at presentation, presenting symptoms, description of last pregnancy, treatmen t, and outcome were analyzed in five patients diagnosed as PSTT in our departmen t from 1973 to 2003. We describe the clinical outcome of 5 patients with PSTT, f our of them were diagnosed and treated since 2001. Mean interval from last pregn ancy until diagnosis was 5.1 months (range 0-10 months). Vaginal bleeding was t he presenting symptom in all the five patients. Instead of standard hysterectomy followed by chemotherapy, when indicated, one patient underwent fertility prese rving management using hysteroscopic resection of the tumor followed by chemothe rapy. The combination of operative hysteroscopy and chemotherapy in women with l ocalized disease, who want to preserve their fertility, can be a possible treatm ent option in highly selected patients. Repeated chemotherapy with EMA/EP, even in patients who relapsed after treatment with EMA/EP for PSTT can induce prolong ed remission and even cure.
Placental site trophoblastic tumor (PSTT) is a rare variant of gestational tro phoblastic disease that has been re-described during the 1970s. The patients’a ge at presentation, presenting symptoms, description of last pregnancy, treatmen t, and outcome were analyzed in five patients diagnosed as PSTT in our departmen t from 1973 to 2003. We describe the clinical outcome of 5 patients with PSTT, f our of them were diagnosed and treated since 2001. Mean interval from last pregn ancy until diagnosis was 5.1 months (range 0-10 months). Vaginal bleeding was t he presenting symptom in all the five patients. Instead of standard hysterectomy followed by chemotherapy, when indicated, one patient underwent fertility prese rving management using hysteroscopic resection of the tumor followed by chemothe rapy. The combination of operative hysteroscopy and chemotherapy in women with l ocalized disease, who want to preserve their fertility, can be a possible treatm ent option in highly selected patients. Repeated chemotherapy with EMA/EP, even in patients who relapsed after treatment with EMA/EP for PSTT can induce prolong ed remission and even cure.
