摘要
Objective: To determine the efficacy of testosterone (T) supplementation on c ognition in a sample of men with Alzheimer disease (AD) or mild cognitive impair ment (MCI). Methods: Fifteen patients with AD and 17 patients with MCI aged 63 t o 85 years completed a randomized, double- blind, placebo- controlled study. N ineteen participants received weekly intramuscular (IM) injections of 100 mg T e nanthate and 13 participants received weekly injections of placebo (saline) for 6 weeks. Cognitive evaluations using a battery of neuropsychological tests were conducted at baseline, week 3, and week 6 of treatment and again after 6 weeks o f washout. Results: Peak serum total T levels were raised from baseline an avera ge of 295% in the active treatment group. Improvements in spatial memory (p < 0.05) and constructional abilities (p < 0.05) and verbal memory were evident in the T group. No changes were noted for selective and divided attention or langua ge. Prostate specific antigen did not significantly change during this brief tre atment. Conclusion: Testosterone supplementation may benefit selective cognitive functions in men with Alzheimer disease and mild cognitive impairment.
Objective: To determine the efficacy of testosterone (T) supplementation on c ognition in a sample of men with Alzheimer disease (AD) or mild cognitive impair ment (MCI). Methods: Fifteen patients with AD and 17 patients with MCI aged 63 t o 85 years completed a randomized, double- blind, placebo- controlled study. N ineteen participants received weekly intramuscular (IM) injections of 100 mg T e nanthate and 13 participants received weekly injections of placebo (saline) for 6 weeks. Cognitive evaluations using a battery of neuropsychological tests were conducted at baseline, week 3, and week 6 of treatment and again after 6 weeks o f washout. Results: Peak serum total T levels were raised from baseline an avera ge of 295% in the active treatment group. Improvements in spatial memory (p < 0.05) and constructional abilities (p < 0.05) and verbal memory were evident in the T group. No changes were noted for selective and divided attention or langua ge. Prostate specific antigen did not significantly change during this brief tre atment. Conclusion: Testosterone supplementation may benefit selective cognitive functions in men with Alzheimer disease and mild cognitive impairment.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第10期50-50,共1页
Digest of the World Core Medical Journals:Clinical Neurology
