摘要
Objective: To investigate the relationship between temporal discrimination thr eshold (TDT) and “off" period gait freezing(OGF) in patients with fluctuating P arkinson disease (PD).Methods: TDT values were measured at the dorsum of the toe s in 11 control subjects and 22 patients with PD with a wearing off phenomenon ( 16 patients with OGF and 6 patients without OGF). Results: During the L-dopa “ off" period, TDT values increased abnormally in both patient groups but were sig nificantly higher in patients with OGF than in those without OGF. A positive cor relation was found between the severity of OGF and TDT values measured by differ ent point stimulation. In patients with OGF, a single dose of L-dopa treatment normalized TDTvalues and ameliorated OGF. Conclusions: Dopa-responsive abnormal discriminative sensory processing may be a possible cause of “off" period gait freezing observed in patients with fluctuating Parkinson disease.
Objective: To investigate the relationship between temporal discrimination thr eshold (TDT) and “off' period gait freezing(OGF) in patients with fluctuating P arkinson disease (PD).Methods: TDT values were measured at the dorsum of the toe s in 11 control subjects and 22 patients with PD with a wearing off phenomenon ( 16 patients with OGF and 6 patients without OGF). Results: During the L-dopa “ off' period, TDT values increased abnormally in both patient groups but were sig nificantly higher in patients with OGF than in those without OGF. A positive cor relation was found between the severity of OGF and TDT values measured by differ ent point stimulation. In patients with OGF, a single dose of L-dopa treatment normalized TDTvalues and ameliorated OGF. Conclusions: Dopa-responsive abnormal discriminative sensory processing may be a possible cause of “off' period gait freezing observed in patients with fluctuating Parkinson disease.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第7期48-48,共1页
Digest of the World Core Medical Journals:Clinical Neurology
