摘要
Context: Physical activity may help maintain cognitive function in older adult s. Objective: To examine the relation of long term regular physical activity, i ncluding walking, to cognitive function. Design: Women reported participation in leisure time physical activities on biennial mailed questionnaires beginning i n 1986. We assessed long term activity by averaging energy expenditures from qu estionnairesin 1986 through participantsbaseline cognitive assessments (1995 t o 2001). We used linear regression to estimate adjusted mean differences in base line cognitive performance and cognitive decline over 2 years, across levels of physical activity and walking. Setting and Participants: NursesHealth Study, i ncluding 18766 US women aged 70 to 81 years. Main Outcome Measure: Validated tel ephone assessments of cognition administered twice approximately 2 years apart ( 1995 to 2001 and 1997 to 2003), including tests of general cognition, verbal mem ory, category fluency, and attention. Results: Higher levels of activity were as sociated with better cognitive performance. On a global score combining results of all 6 tests, women in the second through fifth quintiles of energy expenditur e scored an average of 0.06, 0.06, 0.09, and 0.10 standard units higher than wom en in the lowest quintile (P for trend < .001), Compared with women in the lowest physical acti vity quintile, we found a 20%lower risk of cognitive impairment for women in th e highest quintile of activity. Among women performing the equivalent of walking at an easy pace for at least 1.5 h/wk, mean global scores were 0.06 to 0.07 uni ts higher compared with walking less than 40 min/wk (P ≤.003). We also observed less cognitive decline among women who were more active, especially those in th e 2 highest quintiles of energy expenditure. Women in the fourth and fifth quint iles had mean changes in global scores that were 0.04 (95%confidence interval, 0.02-0.10) and 0.06 (95%confidence interval, 0.02-0.11) standard units better than those in the low
Context: Physical activity may help maintain cognitive function in older adult s. Objective: To examine the relation of long term regular physical activity, i ncluding walking, to cognitive function. Design: Women reported participation in leisure time physical activities on biennial mailed questionnaires beginning i n 1986. We assessed long term activity by averaging energy expenditures from qu estionnairesin 1986 through participantsbaseline cognitive assessments (1995 t o 2001). We used linear regression to estimate adjusted mean differences in base line cognitive performance and cognitive decline over 2 years, across levels of physical activity and walking. Setting and Participants: NursesHealth Study, i ncluding 18766 US women aged 70 to 81 years. Main Outcome Measure: Validated tel ephone assessments of cognition administered twice approximately 2 years apart ( 1995 to 2001 and 1997 to 2003), including tests of general cognition, verbal mem ory, category fluency, and attention. Results: Higher levels of activity were as sociated with better cognitive performance. On a global score combining results of all 6 tests, women in the second through fifth quintiles of energy expenditur e scored an average of 0.06, 0.06, 0.09, and 0.10 standard units higher than wom en in the lowest quintile (P for trend < .001), Compared with women in the lowest physical acti vity quintile, we found a 20%lower risk of cognitive impairment for women in th e highest quintile of activity. Among women performing the equivalent of walking at an easy pace for at least 1.5 h/wk, mean global scores were 0.06 to 0.07 uni ts higher compared with walking less than 40 min/wk (P ≤.003). We also observed less cognitive decline among women who were more active, especially those in th e 2 highest quintiles of energy expenditure. Women in the fourth and fifth quint iles had mean changes in global scores that were 0.04 (95%confidence interval, 0.02-0.10) and 0.06 (95%confidence interval, 0.02-0.11) standard units better than those in the low
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第2期4-5,共2页
Digest of the World Core Medical Journals:Clinical Neurology
