摘要
Objective: To determine the prevalence and impact of comorbid psychiatric disturbances in Parkinson disease (PD) patients with psychosis. Methods: Subject data were derived from a research database of 116 PD patients participating in standardized motor, cognitive, psychiatric, and care giver assessments. Results: There were 25 patients (22% ) with psychosis manifest as hallucinations (n = 9), delusions (n = 1), or hallucinations and delusions (n = 15) and 25 patients (22% ) who had no current or past psychiatric comorbidities (PDN). In the psychotic group, 44% had psychosis only (PSY), and 56% had psychosis plus at least one other comorbid psychiatric disturbance (PSY+ ), including depressive disorders (71% ), anxiety disorders (21% ), apathetic syndromes (14% ), and delirium (14% ). There were no differences in age, sex, education, or age onset or duration of PD among the PSY, PSY+ , and PDN groups. Both psychotic groups had greater motor, functional, and frontal cognitive deficits and increased caregiver burden scores relative to PDN. PSY+ showed greater global and selective cognitive deficits compared to PDN. Psychosis was a primary predictor of caregiver burden, whereas depressive symptoms indirectly enhanced motor impairments. Conclusions: Nonpsychotic psychiatric disturbances, especially affective disturbances, are common comorbidities in PD patients with
Objective: To determine the prevalence and impact of comorbid psychiatric disturbances in Parkinson disease (PD) patients with psychosis. Methods: Subject data were derived from a research database of 116 PD patients participating in standardized motor, cognitive, psychiatric, and care giver assessments. Results: There were 25 patients (22% ) with psychosis manifest as hallucinations (n = 9), delusions (n = 1), or hallucinations and delusions (n = 15) and 25 patients (22% ) who had no current or past psychiatric comorbidities (PDN). In the psychotic group, 44% had psychosis only (PSY), and 56% had psychosis plus at least one other comorbid psychiatric disturbance (PSY+ ), including depressive disorders (71% ), anxiety disorders (21% ), apathetic syndromes (14% ), and delirium (14% ). There were no differences in age, sex, education, or age onset or duration of PD among the PSY, PSY+ , and PDN groups. Both psychotic groups had greater motor, functional, and frontal cognitive deficits and increased caregiver burden scores relative to PDN. PSY+ showed greater global and selective cognitive deficits compared to PDN. Psychosis was a primary predictor of caregiver burden, whereas depressive symptoms indirectly enhanced motor impairments. Conclusions: Nonpsychotic psychiatric disturbances, especially affective disturbances, are common comorbidities in PD patients with psychosis
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第1期36-37,共2页
Digest of the World Core Medical Journals:Clinical Neurology
