摘要
目的 探讨白介素 (IL) 6、1 0、1 2在精神分裂症的病因与发病机制中的作用。方法 采用酶联免疫吸附法 (ELSIA)检测 57例精神分裂症和 2 9名健康对照的血浆IL 6、IL 1 0、IL 1 2水平。结果 精神分裂症患者组血浆IL 1 2水平明显高于对照组 (P <0 0 5) ,而IL 6、IL 1 0水平两组间无显著性差异 ;女性患者的血浆IL 1 0水平明显低于女性对照组 (P <0 0 5) ,其IL 1 2则高于对照组 (P <0 0 5) ;Ⅱ型精神分裂症患者的血浆IL 6水平明显高于Ⅰ型(P <0 0 5) ,家族性亚型患者的IL 6水平明显高于散发性亚型 (P <0 0 1 ) ;患者组IL 6与IL 1 0呈正相关 (P <0 0 0 1 )。结论 精神分裂症患者存在IL 1 2介导的免疫功能异常 ,血浆IL 6水平升高可能是其某些临床亚型的特征性免疫学指标之一 。
Objective To study the pathophysiological mechanisms of interleukin in schizophrenia. Methods Using enzyme linked immuno sorbent assay(ELISA), plasma levels of IL 6, IL 10 and IL 12 were measured in 57 schizophrenic patients and 29 healthy controls. Results Plasma IL 12 was significantly higher in schizophrenic patients than in healthy controls, and there were no significant differences in IL 6 and IL 10 between the two groups. IL 10 level was significantly lower, and IL 12 was significantly higher in female patients compared with female controls. IL 6 was higher in Ⅱ type schizophrenic patients than in Ⅰ type ones, and in familial type patients than in sporadic type ones. Positive correlation was observed between IL 6 and IL 10 in patients. Conclusions The study has shown that schizophrenia may result from immune dysfunction mediated through IL 12. Increased plasma level of IL 6 may be a characteristic immunological parameter for some clinical subtypes of schizophrenia. The correlation between cytokines may be changed in psychopathologic states.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2002年第5期336-338,共3页
Chinese Journal of Nervous and Mental Diseases
