摘要
目的 :研究海口市吸毒人群病毒与甲~庚型肝炎病毒感染状况。方法 :对 2 2 1例吸毒者进行不同因素分析 ,采用巢式 PCR法检测血清中的 TTV DNA,对一株 TTV部分基因序列进行了测定 ;用 EL ISA法检测甲~庚型肝炎病毒。结果 :2 2 1名吸毒人群中 TTV DNA与甲~庚型肝炎病毒感染率分别为 HBV45 .7%、 TTV DNA31.6 %、 HCV11.8%、HGV10 .4%、 HEV2 .2 %、HAV0 .4% ;静脉毒瘾者、有非固定婚外性伴侣等因素与 TTV、HBV、HCV感染有关 ;TTV与甲~庚型肝炎病毒均存在合并感染 ;一株 TTV DNA序列与 Gen Bank中主要序列核苷酸同源性大于 98%。结论 :吸毒人群是 TTV和肝炎病毒感染的高危人群 ,静脉毒瘾者、有非固定性伴侣是 TTV、HBV、HCV传播的重要因素 ,TTV还存在非血源性传播途径 。
Objevtive:To investigate TT virus and hepatitis A to G virus infection among drug users in Haikou.Methods:TTV DNA in serum samples was detected by nested polymeras chain reaction,partial genes of one strain of TTV was cloned and sequerced,and their genetiv variation was analyzed.Hepatitis A to G was detected by ELISA.Results:The positive rate of HBV(45 7%)、TTV DNA(31 6%)、HCV(11 8%)、HGV(10 4%)、HEV(2 2%)、HAV(0 4%) was detected among 221 drug users.The sequence analysis show that there were above 98% nucleotide identity among GenBank.Conclusion:The intravenous drug users are the population at high risk for TTV and hepatitis infection.The intravenous drug users and people who have unsteady sex companion are the main transmission factors for TTV、HBV、HCV.TTV may be transmitted by non blood transfusion routes.
出处
《现代预防医学》
CAS
2000年第3期315-317,共3页
Modern Preventive Medicine
基金
海南省基础性研究项目!(8990 6 )