摘要
本研究通过以医院为基础的帕金森病(PD)病例对照回顾性调查,了解PD病人的家族发病、环境暴露并测定头发中锰、铜、镉、铅和汞元素的含量,分析其与PD的关系。结果提示PD的发生是由遗传易感性、神经系统老化和环境危险因素三者共同作用的结果,原发性PD病人可能存在锰代谢缺陷。
This research, a hospital-based case control study, tried to study the family prevalences of Parkinson's disease (PD) and environmental exposures for PD, and to analyze the relationship between manganese, copper, cadmium, lead, mercury and PD through the measurement of metals in hair of PD cases and matched controls.
The results suggested that PD may be the combined product of genetic susceptibility, ageing of. nervous system and environmental risk factors. The PD patients may have manganese metabolism defect.
出处
《中山医科大学学报》
CSCD
1991年第2期143-147,共5页
Academic Journal of Sun Yat-sen University of Medical Sciences
关键词
震颤性麻痹
病因
遗传易感性
Parkinson's disease Genetic susceptibility Environmental risk factors Manganese metabolism defect
