摘要
目的 探讨肾综合征出血热 (HFRS)患者急性期外周血肿瘤坏死因子 α(TNF α) ,白细胞介素 2 (IL 2 ) ,白细胞介素 6(IL 6) ,白细胞介素 8(IL 8)含量的变化及其临床意义。方法 应用酶联免疫方法 (ELISA)对 3 4例肾综合征出血热患者急性期外周血细胞因子进行检测。结果 HFRS患者血清TNF α ,IL 6及IL 8水平均明显高于对照组 ,且含量随病情加重而升高 ,重型组明显高于中轻型组 ;患者的IL 2则低于对照组 ,重型组较中轻型组明显降低。结论 患者血中上升的TNF α,IL 6及IL 8和下降的IL 2水平均与该病的病理损伤有关 。
Objective To investigate the serum levels of TNF α, IL 2, IL 6, IL 8 in patients with hemorrhagic fever with renal syndrome in acute phase. Methods Serum levels of cytokines were measured by ELISA kits in 34 patients hospitalized with hemorrhagic fever with renal syndrome. Results Serum levels of TNF α,IL 6 and IL 8 in HFRS patients were higher than that in control group and correlated with severity degree, whereas serum level of IL 2 in HFRS patients was lower than that in control group and also correlated with severity degree.Conclusion The increased level of TNF α,IL 6 and IL 8 in HFRS patients are related to the severity degree of the disease.
出处
《临床内科杂志》
CAS
北大核心
2002年第5期345-346,共2页
Journal of Clinical Internal Medicine
基金
卫生部资助课题 ( 96 2 116 )
