摘要
目的观察解郁通痹汤治疗气滞血瘀型冠心病心绞痛的临床疗效及安全性。方法选择2016年1月-2018年6月我院收治的120例气滞血瘀型冠心病心绞痛患者作为研究对象,按随机表法分为治疗组与对照组,各60例。对照组采用西医常规治疗,治疗组在对照组基础上加用解郁通痹汤进行治疗。观察2组的临床治疗效果、中医证候疗效,并统计比较2组心绞痛发作次数改善情况、硝酸甘油停减率及不良反应发生情况。结果治疗4周后,治疗组的总有效率为96.7%,优于对照组的73.3%(P <0.05);治疗组心绞痛发作次数少于对照组,差异存在统计学意义(P <0.05);治疗组硝酸甘油减停率90.0%,优于对照组的55.0%(P <0.01);治疗组中医症状总有效率98.3%,优于对照组的78.3%(P <0.01);治疗组和对照组治疗期间的不良反应发生率分别为6.67%、8.33%,2组间差异无统计学意义(P> 0.05)。结论加用解郁通痹汤治疗可明显改善气滞血瘀型冠心病心绞痛患者的临床症状,提高临床疗效,缩短心绞痛发作次数,且不会增加不良反应。
Objective To observe the clinical efficacy and safety of Jieyu Tongbi Decoction in treating angina pectoris of coronary heart disease with qi stagnation and blood stasis.Methods From January 2016 to June 2018,120 patients with angina pectoris of coronary heart disease with qi stagnation and blood stasis were enrolled in our hospital.The patients were divided into treatment group and control group according to the order of admission,with60 cases in each group.The control group was treated with conventional western medicine,while the treatment group was given Jieyu Tongbi Decoction based on the control group.The ef fect of clinical treatment and TCM syndrome were observed and analyzed,and the times of angina pectoris,the reduction rate of nitroglycerin and the adverse reaction were counted in the two groups.Results After 4 weeks,the total ef fective rate of the treatment group was96.7%,which was better than 73.3%of the control group,the dif ference was statistically significant(P<0.05).The number of angina attacks in the treatment group was less than that of the control group,the dif ference was statistically significant(P<0.05).The reduction rate of nitroglycerin was 90.0%in the treatment group,which was significant higher than 55.0%in the control group(P<0.01).The total ef fective rate of TCM symptoms in the treatment group was 98.3%,which was significant higher than 78.3%in the control group(P<0.01).The incidence of adverse reactions was 6.67%in the treatment group versus 8.33%in control group,and there was no significant dif ference between the two groups(P>0.05).Conclusion The addition of Jieyu Tongbi Decoction can obviously improve the clinical symptoms of patients with angina pectoris of coronary heart disease with qi stagnation and blood stasis,improve the clinical curative effect,shorten the frequency of angina pectoris attack,and not increase the obvious adverse reaction.
作者
李国林
姜雪
刘宁
LI Guolin;JIANG Xue;LIU Ning(Department of Cardiology,The Second People’s Hospital of Dalian City,Dalian 116011,Liaoning Province,China;Educational Administration Section,Dalian Friendship Hospital,Dalian 116001,Liaoning Province,China)
出处
《长春中医药大学学报》
2019年第4期663-666,共4页
Journal of Changchun University of Chinese Medicine
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015041)
关键词
冠心病
心绞痛
胸痹
气滞血瘀
coronary heart disease
angina pectoris
chest bi
qi stagnation and blood stasis
