摘要
目的观察4-苯基丁酸(PBA)对创伤失血性休克大鼠重要器官血流灌注、器官功能及线粒体功能的影响。方法采用创伤失血性休克SD大鼠模型128只,雌雄各半,体重180~220g,观察PBA(5、20、50 mg/kg)对休克大鼠肝、肾血流量,肝、肾功能和线粒体功能的影响。结果休克后肝、肾血流量明显下降,肝、肾功能受损;PBA(20 mg/kg)输注可明显恢复肝血流量,各剂量PBA组的肾血流量均高于乳酸林格氏液(LR)组;PBA(20 mg/kg)明显改善肝肾功能,降低肝、肾功能指标;同时PBA明显改善休克后降低的肝、肾和肠的线粒体功能,其中20mg/kg PBA的作用最为显著。结论 PBA可改善休克动物的肝、肾等重要器官的血流灌注,促进线粒体功能恢复,发挥对重要器官功能的改善作用。
Objective To investigate the effects of 4-phenyl butyric acid( PBA) on blood perfusion,vital organ and mitochondrial function of traumatic hemorrhagic shock rats. Methods With models of traumatic hemorrhagic shock in 128 SD rats,64 female and 64 male with body weight ranged from 180 g to 220 g,the effects of PBA( 5,20,50 mg/kg) on the blood flow in liver and kidney,the function of the liver and kidney and its mitochondrial function were observed. Results The blood flow in liver and kidney was significantly reduced,the damage of liver and kidney function was detected after shock. PBA( 20 mg / kg) significantly increased the liver blood flow,and the renal blood flow in the three doses of PBA groups was higher than in lactated Ringer’s solution( LR) group. PBA( 20mg/kg) improved the liver and kidney function and decreased the index of liver and kidney function. Meanwhile,PBA improved the decreased mitochondrial function in liver,kidney and intestine after shock,and 20 mg / kg of PBA had a better effect. Conclusion PBA could improve blood perfusion in liver and kidney,restore the mitochondrial function,and improve the vital organ function after traumatic hemorrhagic shock.
出处
《创伤外科杂志》
2015年第1期53-56,共4页
Journal of Traumatic Surgery
基金
国家自然科学基金项目(81270400)
国家自然科学基金青年基金项目(30901559)
重庆市基础与前沿研究计划项目(cstc2013jcyj A10012)
关键词
创伤
失血性休克
线粒体
4苯基丁酸
trauma
hemorrhagic shock
mitochondrial
4-phenyl butyric acid
