摘要
目的软肝汤联合熊去氧胆酸治疗原发性胆汁性胆管炎的临床疗效。方法收集我院门诊2016.5~2017.5就诊的64例PBC患者,按数字表法随机分为对照组和治疗组,接受6个月的药物治疗及治疗期间的随访。对照组服用熊去氧胆酸胶囊,治疗组服用软肝汤联合熊去氧胆酸治疗。观察对比患者酶学指标、免疫指标、Firbscan值、证候积分及有效率。结果治疗前治疗组TB水平较对照组高(P<0.05),余项基线指标未见差异;治疗后治疗组ALT、AST、GGT、TB、ALP、IgM、IgG、补体C3、Firbscan值、证候积分变化均有统计学差异(P<0.05);对照组ALT、AST、GGT、TB、ALP、IgG、Firbscan值变化有统计学差异(P<0.05);治疗前后组间比较:治疗组GGT、TB、ALP、IgM、IgG、Firbscan值、证候积分、总有效率优于对照组(P<0.05);治疗过程中无不良事件发生。结论软肝汤联合熊去氧胆酸治疗原发性胆汁性胆管炎安全有效。
Objective：To observe the clinical effect of Ruangan decoction combined with ursodeoxycholic acid in treating primary biliary cholangitis.Method：Sixty-four patients with primary biliary cholangitis（PBC） from 2016.5 to 2017.5 in Shenzhen TCM Hospital were randomly divided into control group and treatment group according to the number table method.They were treated with drugs for 6 months and followed up during the treatment period.The control group was treated with Ursodeoxycholic Acid Capules,and the treatment group was treated with Rugan decoction combined with ursodeoxycholic acid.The enzyme,immune index,Firbscan value,syndrome score and effective rate were observed and compared.Result：The TB level in the treatment group before treatment was higher than that in the control group（P〈0.05）,and there was no difference in the remaining baseline indicators.After treatment,ALT,AST,GGT,TB,ALP,IgM,Igg,complement C3,Firbscan values and syndrome scores showed significant differences in the treatment group,the differences were statistically significant（P〈0.05）.ALT,AST,GGT,TB,ALP,Igg and Firbscan values showed significant differences in thecontrol group,the differences were statistically significant（P〈0.05）.The total effective rate of GGT、TB、ALP、IgM、Igg、Firbsca values and syndrome scores in the treatment group were better than those in the control group（P〈0.05）.No adverse events occurred during the treatment.Conclusion：Ruangan decoction combined with ursodeoxycholic acid is effective and safe in the treatment of primary biliary cholangitis.
作者
姜小艳
唐海鸿
魏春山
童光东
周大桥
黄彬
Jiang Xiaoyan;Tong Guangdong;Tang Haihong;Zhou Daqiao;Wei Chunshan;Huang Bin(The Forth Clinical Medicine School of Guangzhou University of Chinese Medicine,Shenzhen China,518033;Shenzhen TCM Hospital,Shen Zhen China,518033)
出处
《现代中医药》
CAS
2018年第6期33-35,39,共4页
Modern Chinese Medicine
关键词
原发性胆汁性胆管炎
中药
熊去氧胆酸
软肝汤
primary biliary cholangitis
Chinese medicine
ursodeoxycholic acid
Ruangan decoction
