摘要
目的探讨醋酸奥曲肽联合盐酸普萘洛尔治疗肝硬化门静脉高压导致的上消化道出血的效果。方法 2016年10月—2017年5月间方便选取该院96例肝硬化门静脉高压导致上消化道出血的患者进行分析,分为观察组和对照组,各48例患者,对照组采用醋酸奥曲肽进行治疗,观察组在采用醋酸奥曲肽治疗的基础上,还接受盐酸普萘洛尔进行治疗,对两组患者治疗有效率、血流状况、并发症、肝功能指标的变化情况。结果观察组患者的治疗效果与对照组产生明显的差异治疗有效率为97.92%。对照组患者治疗有效率为83.33%,观察组的治疗有效率明显好于对照组,差异有统计学意义(χ~2=6.008,P<0.05)。观察组肝功能指标变化情况好于对照组,观察组治疗前和治疗7 d后的脾静脉血流量分别为(365.8±3.82)mL和(274.3±4.36)mL,对照组患者治疗前和治疗7 d的脾静脉血流量分别为(363.5±3.75)m L和(296.8±4.76)mL,差异有统计学意义(t=4.328,P<0.05)。结论在肝硬化门静脉高压导致上消化道出血治疗中,采用醋酸奥曲肽联合盐酸普萘洛尔进行治疗,疗效确切,患者的肝功能指标得到很大改善,值得在临床上应用。
Objective To study the effect of octreotide acetate combined with propranolole hydrochloride in reducing the upper gastrointestinal bleeding due to cirrhosis and portal hypertension. Methods 96 cases of patients with upper gastrointestinal bleeding due to cirrhosis and portal hypertension admitted and treated in our hospital from October 2016 to May 2017 were selected and divided into two groups with 48 cases in each, the control group were treated with octreotide acetate, while the observation group were treated with octreotide acetate combined with propranolole hydrochloride, and the effective rate, blood flow condition, complication and changes of liver function indicators were compared between the two groups. Results The treatment effective rate in the observation group was obviously better than that in the control group（97.92% vs 83.33%）,,the different was statistically significant（χ^2=6.008,P〈0.05）, and the changes of liver function indicators in the observation group were better than those in the control group, and the splenic venous blood flow amounts before treatment and in 7 d after treatment in the observation group and in the control group were respectively（365.8±3.82）mL,（274.3±4.36）mL, and（363.5±3.75）mL,（296.8±4.76）mL, and the differences were statistically significant（t=4.328,P〈0.05）. Conclusion The curative effect of octreotide acetate combined with propranolole hydrochloride in reducing the upper gastrointestinal bleeding due to cirrhosis and portal hypertension is definite, and the liver function indicators of patients are greatly improved, and it is worth clinical application.
作者
耿世明
GENG Shi-rning(Department of Gastroscopy,Handan Second Hospital,Handan,Hebei Province,056001 China)
出处
《中外医疗》
2018年第32期104-105,108,共3页
China & Foreign Medical Treatment
关键词
醋酸奥曲肽
盐酸普萘洛尔
肝硬化门静脉高压
上消化道出血
Octreotide acetate
Propranolole hydrochloride
Cirrhosis and portal hypertension
Upper gastrointestinal bleeding
