摘要
目的:评价聚乙二醇化重组人粒细胞刺激因子注射液(新瑞白,PEG-GCSF)应用于乳腺癌化疗对患者舒适度及护理的影响。方法:回顾性分析2016年3月至2017年9月在浙江省肿瘤医院行乳腺癌含蒽环联合紫衫方案化疗的100例患者的临床资料,一组使用重组人粒细胞刺激因子(GCSF)共44例,一组使用PEG-GCSF共56例。比较2组药物反应、舒适度评分、抽血次数、护理次数、护理时间。结果:PEG-GCSF组在疼痛平均评分、人均失眠、精神不佳及消化道症状出现次数上均明显小于GCSF组(P <0. 05);在舒适度方面PEG-GCSF组总评分显著高于GCSF组,且PEG-GCSF组在舒适度的生理、精神心理、社会及环境舒适均优于GCSF(P <0. 05); PEG-GCSF组平均抽血次数、单日人均护理次数、人均单次护理时间均显著低于GCSF组(P <0. 05);结论:乳腺癌化疗后应用PEG-GCSF可明显提高患者的舒适度且可减少护理次数与护理时间,减轻护理工作的压力。
[Objective] To evaluate the influences of PEGylated recombinant humangranulocyte-stimulating factor injection （Xinrubai, PEG-GCSF） on breast cancerchemotherapy to patients’ comfort and care. [Method]The clinical data of 100patients with breast cancer including anthracene ring combined with purple shirtchemotherapy in Zhejiang cancer hospital from March 2016 to September 2017 wereretrospectively analyzed. A group of 44 cases were used Recombinant Human Granulocyte Colony-stimulating Factor （GCSF） and a group of 56 cases were treated with PEG-GCSF. The indicators included adverse reaction, comfort score, blood routine number / cycle / number, frequency of care / person / day, nursing time / times / person. [Result] PEG-GCSF group was significantlyless than GCSF group in average pain score, per capita insomnia, mental retardation and gastrointestinalsymptoms. The total score of group PEG-GCSF in PEG-GCSF group was significantlyhigher than that of group GCSF （17.2）, and the PEG-GCSF group was in the physiological and mental psychology of the comfort degree. The social and environmentalcomfort is better than GCSF （ P 〈0.05）. The average number of blood sampling times was 1.3 times in group PEG-GCSF, 16.4 times per day per capita and 7.6 min perperson, which was significantly lower than that in group GCSF （ P〈0.05）. [Conclusion] The application of PEG-GCSF after breast cancer chemotherapycan significantly improve the patient＇s comfort and reduce the number of treatments and nursing time, reducing the pressure of nursing work.
作者
章英
方群英
朱玲
沈芸
YU Xingfei
ZHANG Ying;YU Xingfei;FANG Qunying;ZHU Ling(Zhejiang Cancer Hospital,Hangzhou 310022,China)
出处
《浙江医学教育》
2018年第6期40-42,46,共4页
Zhejiang Medical Education
关键词
聚乙二醇化重组人粒细胞刺激因子
乳腺癌
化疗
护理
pegylated Recombinant Human Granulocyte Colony-stimulating Factor
breast cancer
chemotherapy
nursing care
