摘要
目的:对比研究非瓣膜病心房颤动(房颤)患者服用不同抗凝药物前后焦虑、抑郁和生活质量的变化。方法:选取正在接受华法林抗凝治疗的非瓣膜病房颤患者100例,按照医生判断和患者意愿,其中45例患者口服华法林转换为口服达比加群酯抗凝治疗。根据所服用抗凝药物不同,将患者分为华法林组(53例)和达比加群酯组(45例),于治疗之初及转换抗凝药物治疗6个月后填写焦虑自评量表(Self-rating Anxiety Scale,SAS)、抑郁自评量表(Self-rating Depressiong Scale,SDS)和SF-36健康调查表,并进行药物转换前后的比较。结果:基线时两组焦虑和抑郁的发生率以及SAS、SDS、躯体健康总分(PCS)、精神健康总分(MC)均差异无统计学意义。抗凝治疗6个月后,达比加群酯抗凝组SAS评分(42.78±2.91∶46.0±2.20)与SDS评分(37.92±10.06∶46.07±4.77)均低于华法林组,差异有统计学意义(均P<0.05),生活质量PCS评分(44.21±3.66∶41.42±3.06)与MCS评分(44.07±3.83∶41.07±3.49)均高于华法林组,差异有统计学意义(均P<0.05)。结论:与传统抗凝药物华法林比,新型口服抗凝药物达比加群酯对非瓣膜病房颤患者的焦虑、抑郁和生活质量有积极影响。
Objective：To compare how anxiety,depression and quality of life changed in patients with non-valvular atrial fibrillation between different treatment of warfarin and dabigatran.Method：A total of 100 patients with non-valvular atrial fibrillation undertook warfarin were included,45 patients of them converted to dabigatran with warfarin according to the doctor＇s judgment and the patient＇s wishes.All patients were divided into warfarin group（n=53）and dabigatran group（n=45）.Self-rating Anxiety Scale（SAS）,Self-rating Depressiong Scale（SDS）and the Mos 36-item Short From Health Survey（SF-36）were measured and compared between two groups at the beginning of treatment and 6 months after conversion of anticoagulant.Result：At baseline,there was nosignificant difference in the incidence rate of anxiety and depression,and the score of SAS,SDS,PCS,MC between two groups.After 6 month of treatment,the score of SAS（42.78±2.91 vs.46.0±2.20）and SDS（37.92±10.06 vs.46.07±4.77）were lower,while the score of PCS（44.21±3.66 vs.41.42±3.06）and MCS（44.07±3.83 vs.41.07±3.49）were higher in dabigatran group than those in warfarin group（all P〈0.05）.Conclusion：Compared with warfarin,dabingatran could improve anxiety,depression and quality of life in patients with nonvalvular atrial fibrillation.
作者
关静
王松涛
常瑜
张彬
王红
韩欣
邹月柳
苑雯雯
GUAN Jing;WANG Songtao;CHANG Yu;ZHANG Bin;WANG Hong;HAN Xin;ZOU Yueliu;YUAN Wenwen(Heart Center,Qingdao Fuwai Hospital CAMS ＆ Pume,Qingdao,Shandong,266034,China)
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2018年第11期1069-1072,共4页
Journal of Clinical Cardiology
关键词
心房颤动
焦虑
抑郁
生活质量
华法林
达比加群酯
atrial fibrillation
anxiety
depression
quality of life
warfarin
dabigatran
