摘要
目的探讨益生菌对结肠癌化疗患者肠道菌群的影响。方法 83例结肠癌化疗患者,随机分为观察组(41例)和对照组(42例)。观察组患者化疗同时服用双歧杆菌乳杆菌三联活菌片,对照组患者化疗时不服用双歧杆菌乳杆菌三联活菌片。比较两组患者化疗前后双歧杆菌、乳酸杆菌、大肠杆菌和肠球菌的数目及并发症发生情况。结果化疗前,两组患者双歧杆菌、乳酸杆菌、大肠杆菌和肠球菌每克样品中含有的细菌菌落总数比较,差异无统计学意义(P>0.05)。化疗后,观察组患者双歧杆菌、乳酸杆菌每克样品中含有的细菌菌落总数明显多于对照组,大肠杆菌和肠球菌每克样品中含有的细菌菌落总数明显少于对照组,差异有统计学意义(P<0.05)。化疗后,观察组患者恶心、呕吐、腹泻及食欲下降发生率为19.5%、12.2%、17.1%、36.6%,均明显低于对照组的40.5%、33.3%、38.1%、85.7%,差异有统计学意义(P<0.05)。结论在结肠癌患者化疗期间,使用益生菌可以调整患者的肠道菌群分布,降低化疗后患者并发症发生,值得临床推广。
Objective To discuss the effect of probiotics on intestinal flora in patients with colon cancer undergoing chemotherapy. Methods A total of 83 patients with colon cancer undergoing chemotherapy were randomly divided into observation group（41 cases） and control group（42 cases）. The observation group received Live Combined Bifidobacterium and Lactobacillus Tablets during chemotherapy, and the control group received no live combined bifidobacterium and lactobacillus tablets during chemotherapy. Comparison were made on number of Bifidobacteria, Lactobacilli, Escherichia coli and Enterococci and occurrence of complications before and after chemotherapy between the two groups. Results Before chemotherapy, there was no statistically significant difference in total number of bacterial colonies contained in Bifidobacterium, Lactobacillus, Escherichia coli and Enterococcus per gram sample（P〈0.05）. After chemotherapy, the observation group had obviously more total number of bacterial colonies contained in Bifidobacterium and Lactobacillus per gram sample than the control group, and obviously less total number of Escherichia coli and Enterococcus per gram sample than the control group. Their difference was statistically significant（P〈0.05）. After chemotherapy, the observation group had obviously lower incidence of nausea, vomiting, diarrhea and loss of appetite as 19.5%, 12.2%, 17.1% and 36.6% than 40.5%, 33.3%, 38.1% and 85.7% in the control group, and the difference was statistically significant（P〈0.05）. Conclusion During chemotherapy, probiotics can adjust the distribution of intestinal flora in patients with colon cancer and reduce the complications after chemotherapy, and it is worthy of clinical promotion.
作者
詹玉强
ZHAN Yu-qiang(Department Six of Internal Medicine,Shandong Ningjin County People＇s Hospital,Dezhou 253400,China)
出处
《中国实用医药》
2018年第32期105-107,共3页
China Practical Medicine
关键词
结肠癌
益生菌
化疗
肠道菌群
预后
Colon cancer
Probioties
Chemotherapy
Intestinal flora
Prognosis
