摘要
目的 分析抑郁症睡眠障碍患者应用西酞普兰联合米氮平治疗后的效果.方法 采用随机平行对照法将2015年12月至2017年12月濮阳市精神卫生中心精神科治疗的119例抑郁症睡眠障碍患者分为两组,对照组57例给予西酞普兰治疗,观察组62例联合米氮平治疗,比较两组患者治疗后的效果及睡眠质量、睡眠结构变化情况.结果 观察组总有效率（90.32％）高于对照组（73.68％）,治疗后匹兹堡睡眠质量指数（PSQI）评分低于对照组,睡眠结构快速眼动期（REM）所占比例高于对照组,Ⅰ～Ⅱ期比例低于对照组,两组比较差异有统计学意义（P〈0.05）.结论 西酞普兰联合米氮平能够有效改善抑郁症睡眠障碍患者的睡眠结构,提升睡眠质量.
Objective To analyze the effect of citalopram combined with mirtazapine on patients with depressive sleep disorder .Methods From December 2015 to December 2017, 119 patients with depressive sleep disorder treated by the department of psychiatry in Puyang Mental Health Center were divided into two groups by randomized parallel control , 57 patients in the control group were treated with citalopram , and 62 patients in the observation group were treated with mirtazapine .The clinical efficacy , sleep quality and sleep structure of the two groups were compared .Results The total effective rate （90.32％） in observation group was higher than that in control group （73.68％） , PSQI score was lower than that in the control group after treatment , the proportion of REM sleep structure was higher than that in the control group , and the proportion of Ⅰ-Ⅱ period was lower than that in the control group , the differences were significant （ P〈0.05 ） .Conclusions Citalopram combined with mirtazapine can improve the sleep structure and sleep quality of patients with depressive sleep disorder .
作者
丁利华
Ding Lihua(Department of Clinical Second Branch,Puyang Mental Health Center,Puyang 457000,China)
出处
《中国实用医刊》
2018年第20期115-116,120,共3页
Chinese Journal of Practical Medicine
关键词
抑郁症睡眠障碍
西酞普兰
米氮平
睡眠结构
临床疗效
Depressive sleep disorder
Citalopram
Mirtazapine
Sleep structure
Clinical effect
