摘要
目的观察艾司西酞普兰联合正念认知疗法(MBCT)对广泛性焦虑障碍患者临床症状和生活质量的效果,为广泛性焦虑障碍的治疗提供参考。方法选择72例就诊于天津市安定医院、符合《国际疾病分类(第10版)》(ICD-10)广泛性焦虑障碍诊断标准的患者,采用随机数字表法分为研究组和对照组各36例,研究组给予艾司西酞普兰联合MBCT,对照组单用艾司西酞普兰治疗,于治疗前和治疗8周后采用汉密尔顿焦虑量表(HAMA)、焦虑自评量表(SAS)和健康调查简表(SF-36)进行评定。结果治疗8周后,两组HAMA和SAS评分均较治疗前低,差异均有统计学意义(P均<0. 01),研究组HAMA和SAS评分均低于对照组,差异有统计学意义(P均<0. 01);治疗后研究组SF-36各因子评分及总评分均较治疗前高,差异均有统计学意义(P均<0. 01),对照组SF-36除社会功能、心理健康因子外,其他各因子评分及总评分均较治疗前高,差异有统计学意义(P均<0. 01),治疗后研究组SF-36各因子评分及总评分均高于对照组,差异均有统计学意义(P <0. 05或0. 01)。结论与单用艾司西酞普兰相比,艾司西酞普兰联合MBCT可能更有助于改善广泛性焦虑障碍患者的临床症状和生活质量。
Objective To observe the effect of escitalopram combined with Mindfulness-based Cognitive Therapy（MBCT）on clinical symptoms and quality of life in generalized anxiety disorder patients which aimed to provide references for treatment of generalized anxiety disorder patients. Methods A total of 72 generalized anxiety disorder patients diagnosed with International Classification of Diseases,tenth edition（ ICD-10） in Tianjin Anding Hospital were randomly divided into the study group（ n = 36）and the control group（ n = 36）. The study group was treated with escitalopram combined with MBCT,while the control group was treated with escitalopram. Before and after treatment for 8 weeks,patients were assessed with Hamilton Anxiety Scale（ HAMA）,Self-rating Anxiety Scale（ SAS） and 36-item Short Form Health Survey（ SF-36）. Results After treatment for 8 weeks,the HAMA and SAS scores of the two groups were all lower than before treatment（ all P〈0. 01）. The HAMA and SAS scores of the study group were lower than those of the control group（ all P〈0. 01）. After treatment,the SF-36 factors scores and total score of the study group were higher than before treatment（ all P〈0. 01）. In the control group,SF-36 factors scores and total score,except social function and mental health,were higher than those before treatment（ all P〈0. 01）. After treatment,the SF-36 factor scores and total score of the study group were higher than those of the control group（ all P〈0. 05 or 0. 01）. Conclusion Compared with escitalopram monotherapy,the combination of escitalopram and MBCT may be more helpful in improving clinical symptoms and quality of life in patients with generalized anxiety disorder.
作者
孙磊
陈清刚
王莹
王川
邹琳
Sun Lei;Chen Qinggang;Wang Ying;Wang Chuan;Zou Lin(Tianjin Anding Hospital,Tianjin 300222,China)
出处
《四川精神卫生》
2018年第5期428-431,共4页
Sichuan Mental Health
基金
2017年度天津市安定医院院级课题
关键词
正念认知疗法
广泛性焦虑障碍
临床症状
生活质量
Mindfulness -based Cognitive Therapy
Generalized anxiety disorder
Clinical symptoms
Life quality
