摘要
5-HT作为一种重要的神经递质,不仅参与了支气管哮喘、精神分裂症等疾病的发生,还对骨代谢有着重要的影响。中枢5-HT可通过Tph2抑制交感神经兴奋并促进骨形成。Lrp5可降低外周5-HT水平并作用在Tph1达到促进骨形成的作用。外周5-HT阻断转录因子FOXO1与环磷腺苷效应元件结合蛋白(CREB)之间的联系,并抑制骨生成,外周5-HT还可促进IL-6的表达诱导骨重吸收。研究发现LP533401作为Tph1抑制剂可有效地降低外周5-HT的水平,诱导骨形成。文章就5-HT对骨代谢的影响及其作用机制、如何利用5-HT有效地调控骨量进行综述。
5-HT as an important neurotransmitter which takes part in the development of many diseases, including bronchial asthma,schizophrenia and bone metabolism as reported in literatures in recent years. Central 5-HT can inhibit sympathetic excitations and promote bone formation through Tph2. Lrp5 can reduce the level of peripheral 5-HT and act on Tph1 to promote bone formation. Peripheral 5-HT blocks the association between transcription factor FOXO1 and CREB and inhibits bone formation. Peripheral 5-HT can also promote IL-6 expression and induce bone reabsorption. LP533401 as a Tph1 inhibitor could effectively reduce the level of peripheral 5-HT and induce bone formation as reported. In this paper, we try to summarize the effect of 5-HT on bone metabolism and its mechanism, and further using 5-HT to regulate bone quantity effectively.
作者
柏茂盛
薛凯文
赵建宁
BAI Mao-sheng;XUE Kai-wen reviewing;ZHAO Jian-ning checking(Department of Orthopedics,Jinling Hospital,Medical School of Nanjing University/Nanjing General Hospital of Nanjing Military Region,PLA,Nanjing 210002,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2018年第11期1201-1206,共6页
Journal of Medical Postgraduates
基金
国家自然科学基金(81772318)
关键词
5-羟色胺
色氨酸羟化酶
5-HT受体
骨代谢
5-hydroxytryptamine
tryptophanhydroxylase
5-hydroxytryptamine receptor
bone metabolism
