摘要
目的探讨丁苯酞联合脑心通胶囊治疗脑梗死的效果及对侧支循环血流速度的影响。方法选取2015年5月～2018年5月中南大学湘雅医学院附属海口医院及湖南省第二人民医院收治的脑梗死患者147例为研究对象。按照随机数字表法将其分为对照组(n=73)和研究组(n=74),对照组患者给予丁苯酞治疗,研究组采用丁苯酞联合脑心通胶囊治疗。比较两组患者治疗后临床效果、治疗前后侧支循环血流速度[大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)]、血清炎性因子水平[白细胞介素(IL)-6、IL-10、C反应蛋白(CRP)],同时观察两组患者治疗期间不良反应发生情况。结果治疗后,研究组临床总有效率为97.30%(72/74),显著高于对照组的82.19%(60/73),差异有统计学意义(P <0.05)。两组患者治疗后ACA、PCA血流速度均较治疗前降低,且研究组低于对照组(P <0.05);MCA血流速度较治疗前升高,且研究组高于对照组(P <0.05)。两组患者治疗后IL-6、IL-10以及CRP均较治疗前降低,且研究组低于对照组(P <0.05)。两组患者治疗期间不良反应总发生率比较差异无统计学意义(P> 0.05)。结论丁苯酞联合脑心通胶囊治疗脑梗死,效果确切,可有效改善侧支循环血流速度,降低患者炎性因子水平,且不增加不良反应发生率,具有较高的临床应用价值。
Objective To explore the curative effect of Butylphthalide combined with Naoxintong Capsules on cerebral infarction and its effect on blood flow velocity of collateral circulation. Methods One hundred and forty-seven patients with cerebral infarction admitted to Affiliated Haikou Hospital of Xiangya Medical College, Central South University and the Second People′s Hospital of Hunan Province from May 2015 to May 2018 were selected as the research subjects. The patients were divided into the control group （n = 73） and the study group （n = 74） according to random number table method. The control group was treated by Butylphthalide, and the study group was treated by Butylphthalide combined with Naoxintong Capsules. The clinical efficacy of the two groups after treatment was compared, the flow velocity of collateral circulation in the two groups [anterior cerebral artery （ACA）, middle cerebral artery （MCA）, posterior cerebral artery （PCA）], serum inflammatory factor level [interleukin （IL） -6, IL-10, C reverse protein （CRP）] before and after treatment were compared, the occurrence of adverse reactions in the two groups during the treatment were observed. Results After treatment, the total clinical effective rate of the study group was 97.30%（72/74）, which was significantly higher than 82.19%（60/73） of the control group, the difference was statistically significant （P 〈 0.05）. The blood flow velocity of ACA and PCA of the two groups after treatment were lower than those before treatment, which of the study group was lower than those of the control group （P 〈 0.05）; the blood flow velocity of MCA was higher than that before treatment, which of the study group was higher than that of the control group （P 〈 0.05）. After treatment, the levels of IL-6, IL-10 and CRP of the two groups decreased compared with those before treatment, which of the study group were lower than those of the control group （P 〈 0.05）. There was no significant difference in the incidence
作者
杨敏慧
刘爱群
向光红
YANG Minhui;LIU Aiqun;XIANG Guanghong(Department of Neurology,Affiliated Haikou Hospital of Xiangya Medical College,Central South University,Hainan Province,Haikou,570208,China;Department of Neurology,the First Affiliated Hospital of Guangdong Pharmaceutical University,Gungdong Province,Guangzhou,510008,China;Department of Neurology,the Second People′s Hospital of Hu′nan Province,Hu′nan Province,Changsha,410007,China)
出处
《中国医药导报》
CAS
2018年第33期93-97,共5页
China Medical Herald
基金
海南省普通医学科研项目(2014-056)
关键词
丁苯酞
脑心通胶囊
脑梗死
血流速度
Butylphthalide
Naoxintong Capsules
Cerebral infarction
Blood flow velocity
