摘要
RAS基因家族包含3种原癌基因,即KRAS、NRAS和HRAS。在多种肿瘤中RAS基因突变使其激活成为有致癌活性的癌基因。点突变、表达量升高以及插入/转位突变等是其常见的激活方式。深入了解RAS基因家族的突变特征以及其在各种肿瘤中的发生率,可以对肿瘤的发生、发展、早期诊断、靶向治疗以及预后起到很好的指导作用。本文分别从KRAS基因突变、NRAS基因突变以及HRAS基因突变3个方面,对RAS基因家族在实体瘤中突变率的研究进展进行文献回顾。
The RAS gene family contains three proto-oncogenes, namely KRAS, NRAS and HRAS. Mu- tations in a RAS gene in a variety of tumors activate it into an activated oncogene. Single point mutations, increased expression levels, and insertion/translocation mutations are common activation modes. A deep understanding of the mutation characteristics of the RAS gene family and its incidence in various tumors can play a good guiding role in tumor occurrence, development, early diagnosis, targeted therapy and prognosis. This paper gives a review of the literature on the mutation rate of RAS gene families in solid tumors from three aspects： KRAS gene mutation, NRAS gene mutation and HRAS gene mutation.
作者
杨麒巍
隋玉杰
杜珍武
张桂珍
YANG Qiwei;SUI Yujie;DU Zhenwu;ZHANG Guizhen(Second Hospital of Jilin University,Medical Research Center,Changchun 130041,China;Second Hospital of Jilin University,Orthopedics Institute,Changchun 130041,China;Changehun Tumor Hospital,Changchun 130012,China)
出处
《中国体视学与图像分析》
2018年第3期303-310,共8页
Chinese Journal of Stereology and Image Analysis
基金
吉林省教育厅项目(JJKH20170853KJ)
吉林省科技厅项目(20180520111JH)
国家自然科学基金(81702195)
吉林省精准医学分子诊断应用示范项目(2016-2018
NDRC)
吉林省卫计委项目(20180520125JH)
吉林大学白求恩青年基金项目(2015409)
