摘要
活化血小板在子宫内膜异位症(EM)病理过程中起着重要作用,但其作用只是导致内异症发展的一个重要因素。活化血小板与EM患者病灶周期性出血、雌激素受体β、自然杀伤细胞、巨噬细胞、细胞上皮-间充质转分化之间存在密切关联,使用葛根素、表没食子儿茶素没食子酸酯、穿心莲内脂、丙戊酸以及中药复方等抗血小板相关药物能在一定程度上治疗EM。本文就活化血小板与EM病理过程关系进行综述,探讨抗血小板单成分化学药物与活血化瘀中药复方治疗EM的可行性。
Activated platelets play an important role in the pathological process of endometriosis （EM）,but its role is only an important factor leading to the development of endometriosis.Some studies revealed that there was close association between activated platelets and periodic bleeding,estrogen receptor beta,natural killer cells,macrophages ＆ epithelial-mesenchymal transition in endometriosis patients.The drugs,such as puerarin,epigallocatechin gallate,andrographolide,valproic acid,and traditional Chinese medicine related antiplatelet can partially treat EM.In this paper,the relationship between activated platelets and pathological process of EM was reviewed,and the feasibility of anti-platelet single component chemical drugs and traditional Chinese medicine for activating blood and removing stasis in the treatment of EM was discussed.
作者
倪喆鑫
张丹英
姚睿嫔
翟东霞
俞瑾
孙帅
程雯
毕艳丽
俞超芹
NI Zhe-xin;ZHANG Dan-ying;YAO Rui-pin;ZHAI Dong-xia;YU Jin;SUN Shuai;CHENG Wen;BI Yan-li;YU Chao-qin(Department of TCM Gynecology,Changhai Hospital,the Second Military Medical University,Shanghai 20043)
出处
《生殖医学杂志》
CAS
2018年第12期1250-1254,共5页
Journal of Reproductive Medicine
基金
国家自然科学基金面上项目(81774352
81573755)
国家自然科学基金青年科学基金项目(81703874
81503604)
上海市中医药发展三年行动计划项目(ZY3-CCCX-3-7002)
上海市卫计委中医诊疗能力专项-中医妇科诊治能力建设
