摘要
目的观察阿托伐他汀对冠心病心绞痛患者CXCL型趋化因子及血管内皮损伤指标的影响.方法选取2016年2月至2017年7月期间攀枝花市中心医院收治的86例冠心病心绞痛患者为研究对象,将所有患者根据随机数字表法分为对照组和观察组每组各43例.对照组在常规治疗的基础上加用辛伐他汀,观察组则在常规治疗的基础上加用阿托伐他汀.统计与比较2组患者的心绞痛治疗效果、不良反应发生率、治疗前后的CXCL型趋化因子及血管内皮损伤指标.结果观察组的心绞痛治疗总有效率显著高于对照组,差异有统计学意义(P<0.05),2组的不良反应发生率比较,差异无统计学意义(P>0.05),治疗前2组患者的血清CXCL型趋化因子及血管内皮损伤指标比较,差异无统计学意义(P>0.05),治疗后观察组的血清PGI2水平高于对照组,血清CXCL型趋化因子及其他血管内皮损伤指标低于对照组,差异有统计学意义(P<0.05).结论阿托伐他汀在冠心病心绞痛患者中的治疗效果较好,安全性较高,且对CXCL型趋化因子及血管内皮损伤指标具有较好的改善作用,因此在冠心病心绞痛患者中具有较高的应用价值.
Objective To study and observe the influence of atorvastatin for the CXCL chemokines and vascular endothelial damage indexes of patients with angina pectoris of coronary heart disease.Methods 86 patients with angina pectoris of coronary heart disease in our hospital from February 2016 to July 2017 were selected as the study objects,and all the patients were divided into the control group and the observation group with 43 cases in each group according to the random number table.The control group were treated with simvastatin on the basis of routine treatment, and the observation group were treated with atorvastatin on the basis of routine treatment.Then the treatment effect of angina pectoris, adverse reaction rates, CXCL chemokines and vascular endothelial damage indexes before and after the treatment of two groups were analyzed and compared.Results The total effective rate of observation group with angina pectoris was significantly higher than that of control group,so the difference had statistical significance（P 〈0.05）,the adverse reaction rates of two groups were compared,so the difference had no statistical significance（P 〈0.05）,the CXCL chemokines and vascular endothelial damage indexes of two groups before the treatment were compared,and the differenceshad no statistical significance（P 〈0.05）,the serum PGI2 of observation group after the treatment were lower than those of control group,the serum CXCL chemokines and other vascular endothelial damage indexes were lower than those of control group,and the differences had statistical significance（P 〈0.05）. Conclusions The treatment effect of atorvastatin in the patients with angina pectoris of coronary heart disease is better, and its safety is higher,and it has a better improvement role for the CXCL chemokines and vascular endothelial damage indexes,so it has a higher application value in the patients with angina pectoris of coronary heart disease.
作者
赵貤
晏子俊
ZHAO Yi;YAN Zi-jun(Dept.of Pharmacy,Central Hospital of Panzhihua City in Sichuan Province,Panzhihua Sichuan 617067,China)
出处
《昆明医科大学学报》
CAS
2018年第8期59-63,共5页
Journal of Kunming Medical University
基金
四川省科学技术研究与发展计划基金资助项目(MSD2017003)
关键词
阿托伐他汀
冠心病心绞痛
CXCL型趋化因子
血管内皮损伤指标
Torvastatin
Angina pectoris of coronary heart disease
CXCL chemokines
Vascularendothelial damage indexes
