摘要
长链非编码RNA(long non-coding RNA,lncRNA)参与肿瘤的多种生理、病理进程.研究表明,lncRNA可通过与微小RNA (microRNA, mi RNA)反应元件相互作用,并与其他RNA分子形成竞争性内源RNA (competing endogenous RNA,ceRNA)的调控网络,参与基因的表达调控.lncRNA以ceRNA方式参与非小细胞肺癌(non-small cell lung cancer,NSCLC)的发生发展过程,为揭示NSCLC的分子机理开拓了新的思路,也为NSCLC的治疗提供新的靶点.本文在课题组前期发现NSCLC相关ceRNA基础上,主要讨论lncRNA作为ceRNA在NSCLC中高表达、低表达及治疗相关方面的作用.
Long non-coding RNA （lncRNA） is involved in various physiological and pathological processes of tumors. Studies have shown that lncRNAs can participate in gene expression regulation by interacting with microRNA （miRNA） response elements （MREs） and forming a competitive endogenous RNA （ceRNA） regulatory network with other RNA molecules. The lncRNA plays an important role in non-small cell lung cancer （NSCLC） development via ceRNA function. It provides valuable insights into the molecular mechanism of NSCLC and novel targets for precision medicine of NSCLC. This review is based on our previous discovery of lung cancer-related ceRNAs and focuses on the role of lncRNA by acting as highly/lowly expressed and therapeutic ceRNAs in NSCLC.
作者
潘金昌
孟小丹
龚朝辉
PAN Jin-Chang;MENG Xiao-Dan;GONG Zhao-Hui(Institute of Biochemistry and Molecular Biology,Medical School of Ningbo University,Ningbo 315211,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2018年第11期1126-1135,共10页
Progress In Biochemistry and Biophysics
基金
浙江省科技厅公益研究计划(LGF18H160006)
浙江省自然科学基金(LQ18H200001)
宁波市自然科学基金(2017A610247)
宁波市创新团队(2017C110019)
全国大学生创新创业训练计划(201711646018)
王宽诚基金资助项目~~
关键词
长链非编码RNA
竞争性内源RNA
非小细胞肺癌
耐药
long noncoding RNA
competitive endogenous RNA
non-small cell lung cancer
drug resistance
