摘要
目的观察右美托咪定在无创正压机械通气(NIPPV)治疗急性左心衰中的疗效。方法 52急性左心衰竭患者随机分为治疗组和对照组,每组26例,所有患者在常规抗心衰治疗无效后即予以NIPPV,治疗组加用右美托咪定辅助治疗。比较2组治疗后24 h的呼吸频率(RR)、外周血氧饱和度(Sp O2)、p H、动脉血氧分压(Pa O2)、二氧化碳分压(PCO2)、射血分数(EF)、心输出量(CO)、心脏指数(CI)、心率(HR)、脑尿钠肽(BNP)、平均动脉压(MABP)、气管插管率及疗效。结果治疗后24 h,治疗组患者的RR、Pa CO2、HR、BNP、MABP明显低于对照组,SPO2、p H、Pa O2、EF、CO明显高于对照组,疗效优于对照组(P<0.05或0.01)。结论右美托咪定辅助NIPPV治疗急性左心衰竭,可改善患者的心功能,更好地纠正低氧血症,提高疗效。
Objective To evaluate the curative effect of dexmedetomidine in the treatment of acute left heart failure with non-invasive positive pressure ventilation（NIPPV）. Methods52 cases of acute left heart failure that received NIPPV treatment in our department were randomly divided into Therapy Group and Control Group, 26 cases in each group. All the patients were treated with NIPPV after the failure in routine anti-heart failure treatment and the Therapy Group received adjuvant therapy with dexmedetomidine. The RR, Sp O2, p H, Pa O2, PCO2, EF, CO, CI, HR, BNP, MABP and tracheal intubation rate 24 h after the treatment as well as the curative effect of both groups were compared. 24 h after the Results treatment, the Therapy Group had the RR, Pa CO2, HR, BNP and MABP significantly lower than the Control Group and the SPO2, p H, Pa O2, EF and CO significantly higher than the Control Group. The Therapy Group was superior to the Control Group in terms of curative effect（P〈0.05 or 0.01）. Dexmedetomidine-assisted NIPPV for the treatment of left Conclusionheart failure can improve the cardiac function of patients and better correct hypoxemia and improve curative effect.
作者
张日霖
陈淑玲
李庆军
叶小敏
邵月玲
林萍
宁奕明
ZHANG Ri-lin;CHEN Shu-ling;LI Qing-jun;YE Xiao-min;SHAO Yue-ling;LIN Ping;NING Yi-ming(CCU,Central People＇s Hospital of Zhanjiang,Zhanjiang 524037,China;Department of Internal Medicine,Wuchuan Maternal and Child Health Hospital,Wuchuan 524000,China)
出处
《广东医科大学学报》
2018年第4期473-475,共3页
Journal of Guangdong Medical University
关键词
右美托咪定
无创正压机械通气
急性左心衰
临床应用
dexmedetomidine
noninvasive positive pressure ventilation
acute left heart failure
clinical application
