摘要
目的探讨右美托咪定(Dex)联合羟考酮(Oxy)用于全身麻醉胆囊切除患者术后自控静脉镇痛的安全性和有效性。方法选取2017年1—10月北部战区总医院收治的60例择期腹腔镜下行胆囊切除术患者为研究对象。将患者随机分为Oxy组(O组,n=30)和Oxy联合Dex组(OD组,n=30)。比较两组患者术后1、4、8、12、24、36 h的收缩压(SBP)、舒张压(DBP)、心率(HR)、呼吸频率(RR)、脉搏氧饱和度(Sp O2)水平及视觉模拟评分(VAS)、Ramsay镇静评分,观察两组患者的不良反应发生情况。结果两组患者各时间点的SBP、DBP、HR、RR及Sp O2水平比较,差异均无统计学意义(P> 0. 05)。两组患者各时间点VAS评分比较,差异均无统计学意义(P> 0. 05); OD组各时间点Ramsay镇静评分均高于O组,两组间比较,差异有统计学意义(P <0. 05)。OD组恶心呕吐、瘙痒、腹胀及呼吸抑制等不良反应发生率均低于O组,两组间比较,差异有统计学意义(P <0. 05)。结论 Oxy联合Dex应用于胆囊切除患者术后自控静脉镇痛安全、有效,不良反应少。
Objective To investigate the advantage of dexmedetomidine（Dex）combined with oxycodone（Oxy）for patient-control intravenous analgesia（PCIA）after laproscopic cholecystectomy under general analgesia.Methods A retrospective study was performed on 60 cases of patients undergoing laproscopic cholecystectomy who were admitted from January to October of 2017.Patients were randomly divided into the Oxy group（O group, n =30）and Oxy combined Dex group（OD group, n =30）.Postoperative systolic blood pressure（SBP）,diastolic blood pressure（DBP）,heart rate（HR）,respiratory rate（RR）,pulse oxygen saturation（SpO 2）level,visual simulation score（VAS）and Ramsay sedation score were compared between the two groups,and adverse reactions were observed.Results SBP,DBP,HR,RR and SpO 2 levels of the two groups at each time point were compared,and the differences were not statistically significant（ P 〉0.05）.The VAS scores of the two groups at each time point were compared,and the differences were not statistically significant（ P 〉0.05）.Ramsay sedation score in OD group was higher than that in O group at all time points,and the difference was statistically significant（ P 〈0.05）.The incidence of adverse reactions including nausea and vomiting,pruritus,abdominal distension and respiratory inhibition in the OD group was lower than those in the O group,and the difference between the two groups was statistically significant（ P 〈0.05）.Conclusion Dex combined with Oxy is safe,effective and less adverse reactions in patients with PCIA undergoing cholecystectomy.
作者
李桂芹
刘纪泽
刁玉刚
李林
LI Gui-qin;LIU Ji-ze;DIAO Yu-gang;LI Lin(Department of Anesthesiology,General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《创伤与急危重病医学》
2018年第6期392-395,共4页
Trauma and Critical Care Medicine
关键词
羟考酮
右美托咪定
胆囊切除术
自控静脉镇痛
Oxycodone
Dexmedetomidine
Laproscopic cholecystectomy
Patient-control intravenous analgesia
