摘要
目的评价复发性急性胰腺炎(RAP)发病的危险因素和不同治疗方法的疗效。方法回顾性分析326例RAP患者的临床资料,分别采用内镜治疗(A组,n=105)、手术治疗(B组,n=81)与药物治疗(C组,n=140)。采用单因素和多因素Logistics回归分析评价RAP发病的危险因素,比较三组患者的疗效和RAP复发率。结果 RAP的发病率为23. 6%,致病因主要为胆源性因素、高脂血症和酒精性因素。多因素Logistics回归分析表明,高CT评分、三酰甘油、高血糖与暴饮暴食是患者发生RAP的独立危险因素(P均<0. 05)。三组患者无效、好转与治愈患者比例比较,差异未见统计学意义(χ~2=3. 316、0. 786、1. 241,P=0. 191、0. 675、0. 538),复发率比较差异有统计学意义(χ~2=57. 183,P <0. 001)。与C组比较,A组(χ~2=44. 228,P <0. 001)与B组(χ~2=28. 090,P <0. 001)复发率显著降低。结论高CT评分、高三酰甘油、高血糖与暴饮暴食是RAP发病的独立危险因素,应当采用个体化方法治疗RAP,进而减少RAP复发,提高治愈率。
Objective To evaluate the risk factors of recurrent acute pancreatitis（ RAP） and the efficacy of different treatments. Methods A total of 326 patients with RAP who were treated with digestive medicine in our hospital were selected. The patients were divided into endoscopic treatment group（ group A,n = 105）,surgical treatment group（ group B,n = 81） and drug treatment group（ group C,n = 140） according to different treatment methods. Univariate and multivariate logistic regression analysis were used to evaluate the risk factors of RAP. The efficacy and RAP recurrence rate were compared between the three groups. Results The incidence of RAP was 23. 6%. The main causes were biliary factors,hyperlipidemia and alcohol. Multivariate logistic regression analysis showed that high CT score, high triglyceride,hyperglycemia and overeating were independent risk factors for RAP（ P〈0. 05）. There was no significant difference in the proportion of patients who were ineffective,improved,and cured in the three groups（ χ^2= 3. 316,0. 786,1. 241,P = 0. 191,0. 675,0. 538）. The difference in recurrence rate was statistically significant（ χ^2= 57. 183,P〈0. 001）. Compared with group C,the recurrence rate was significantly lower in group A（ χ^2= 44. 228,P〈0. 001） and group B（ χ^2=28. 090,P〈0. 001）. Conclusions High CT score,high triglyceride,hyperglycemia and overeating are independent risk factors for RAP. Individualized treatment should be used to treat RAP,which can reduce RAP recurrence and improve the cure rate.
作者
孟淑娟
Meng Shujuan(Department of Physical Examination,the Second People＇sHospital of Xiayi,Xiayi 476400,China)
出处
《临床医学》
CAS
2018年第10期46-48,共3页
Clinical Medicine
