摘要
制备双氯芬酸钠温敏凝胶剂并考察其体外释放特征。以双氯芬酸钠为主药,泊洛沙姆407和泊洛沙姆188为凝胶材料,聚乙二醇2000,聚乙二醇4000和聚乙二醇6000为渗透促进剂,冷溶法制备双氯芬酸钠温敏凝胶;考察不同型号聚乙二醇、凝胶材料比例对胶凝温度的影响;采用Franz扩散池透皮实验并利用UV法考察其体外释放规律。体外释放结果显示在胶凝温度分别为32、34、36℃环境下,将双氯芬酸钠制备成添加聚乙二醇的温敏凝胶,可显著增加药物溶出速率。
To prepare diclofenac sodium thermosensitive gel and investigate its release characteristics iu vitro. The medicines were given with diclofenac sodium as main medicine, poloxamer 407 and poloxamer 188 as gel materials, polyethylene glycol 2000, polyethylene glycol 4000 and polyethylene glycol 6000 as osmosis promoter, the diclofenac sodium gel was prepared with cold cut method; the effects of different types of polyethylene glycol and proportion of gel materials on gelation temperature were investigated. In this paper, the percutaneous experiment of Franz diffusion pool and the UV method were used to investigate the releasing rule iu vitro. The iu vitro releasing results showed that with the gelation temperature at 32, 34, 36 ℃ environment, on preparation of diclofenac sodium into thermosensitive gel with addition of polyethylene glycol, the process could significantly increase the drug dissolution rate.
作者
施璐
柳晓凤
王宏
何星品
韦燕凤
曹晓琴
方振峰
LIU Xiaofeng;WANG Hong;HE Xingpin;WEI Yanfeng;CAO Xiaoqin;FANG Zhenfeng(Department of Pharmacy,School of Medicine,Jianghan University,Wuhan 430056,Hubei,China)
出处
《江汉大学学报（自然科学版）》
2018年第6期538-542,共5页
Journal of Jianghan University：Natural Science Edition
基金
湖北省教育厅指导性项目(B2017276)
关键词
双氯芬酸钠
温敏凝胶
聚乙二醇
体外释放
胶凝温度
diclofenac sodium
thermosensitive gel
polyethylene glycol
iu vitro release
gelationtemperature
