摘要
为了探究泰地罗新在猪体内的药物动力学特征以及口服生物利用度,本试验通过给猪单次口服和静脉注射泰地罗新,来研究泰地罗新在猪体内的药物动力学特征以及生物利用度。试验结果显示,泰地罗新口服在猪体内吸收半衰期（t1/2ka）为1. 057 h,消除半衰期（t1/2β）为80. 9h,达峰时间（Tmax）为2. 10 h,峰浓度（Cmax）为0. 51μg/m L,其吸收快,消除半衰期长,单次口服给药可长时间维持较高的血药浓度,口服给药在猪体内的生物利用度为72. 9%。研究表明,说泰地罗新在猪体内的口服生物利用度较高,在猪体内分布广,口服和静注的消除半衰期无明显差异,较为适合口服给药。
The pharmacokinetics and bioavailability of Tidipirosin in pig after oral administrationandintravenous injectionwere studied here. The results showed that the main pharmacokinetic parameters of oraladministration were： t1/2ka for 1. 057 h, t1/213 for 80. 9 h, Tmax for 2. 10 h, and Cmax being 0. 51μg/mL, which indicated that tidipirosinwas ofquick absorption and slow elimination, so that a single oral input could maintain a high blood concentration for a long time. The bioavailability of oral administration in pigs was 72. 9%. Therefore, Tildipirosin had high oral bioavailabilityand wide distribution in pigs. However, no significant difference was observed in the elimination half-life between oral and intravenous administrations. In conclusion, Tildipirosin was more suitable for oral administration.
作者
李在建
张书阅
刘文强
秦绪岭
孟喜龙
LI Zaijian;ZHANG Shuyue;LIU Wenqiang;QIN Xuling;MENG Xilong(College of Agriculture,Liaocheng University,Liaocheng 252000,China)
出处
《畜牧与兽医》
北大核心
2018年第11期60-63,共4页
Animal Husbandry & Veterinary Medicine
基金
山东省自然科学基金(ZR2016CL16)
聊城大学大学生创新训练项目(CXCY2018178)
