摘要
目的探讨胎盘生长因子和血红素加氧酶-1在子痫前期发病中的作用。方法选择2014年1月—2017年1月丽水市人民医院产科轻度子痫前期孕妇90例为轻度子痫前期组,90例重度子痫前期孕妇为重度子痫前期组,90例健康孕妇为对照组。采用酶联免疫吸附试验(ELISA)法测定血清胎盘生长因子和血红素加氧酶-1水平。结果 3组孕妇24小时尿蛋白、平均动脉压、血清胎盘生长因子、血红素加氧酶-1水平差异均有统计学意义(P <0. 05)。轻度子痫前期组和重度子痫前期组24小时尿蛋白和平均动脉压均高于对照组(P <0. 05),重度子痫前期组24小时尿蛋白和平均动脉压高于轻度子痫前期组(P <0. 05)。轻度子痫前期组和重度子痫前期组血清胎盘生长因子、血红素加氧酶-1水平均低于对照组(均P <0. 05),重度子痫前期组血清胎盘生长因子和血红素加氧酶-1水平均低于轻度子痫前期组(均P <0. 05)。子痫前期孕妇血清胎盘生长因子、血红素加氧酶-1水平与24小时尿蛋白、平均动脉压均呈负相关(均P <0. 05)。子痫前期孕妇血清胎盘生长因子与血清血红素加氧酶-1水平呈正相关(均P <0. 05)。结论子痫前期孕妇血清胎盘生长因子与血清血红素加氧酶-1水平降低,血清胎盘生长因子与血清血红素加氧酶-1水平与子痫前期的严重程度有关,两者可能在子痫前期的发病过程中相互作用,共同参与子痫前期的发生发展。
Objective To investigate the role of human placental growth factor and human heme oxygenase-1 in the pathogenesis of preeclampsia. Methods Ninety cases of mild preeclampsia pregnant women were selected as mild preeclampsia group 90 cases of severe preeclampsia pregnant women were selected as severe preeclampsia group and 90 healthy pregnant women were selected as control group from January, 2014 to January, 2017 in Lishui City People＇ s Hospital obstetric. The serum levels of placental growth factor and heine oxygenase-1 were determined by enzyme-linked immunosorbent assay （ELISA）. Results The levels of 24 h urinary protein mean arterial pressure serum placental growth factor and heme oxygenase-1 among the three groups were statistically significant （ P 〈 0.05 ）. The 24 h urinary protein and mean arterial pressure in mild preeclampsia group and severe preeclampsia group were significantly higher than that in control group （ P 〈 0.05 ）. The 24 h urinary protein and mean arterial pressure in severe preeclampsia group were significantly higher than that in mild preeclampsia group （ P 〈 0. 05 ）. The levels of serum placental growth factor and heme oxygenase-1 in mild preeclampsia group and severe preeclampsia group were lower than those in control group （ P 〈 0.05 ）. The levels of serum placental growth factor and heme oxygenase-1 in severe preeclampsia group were lower than those in mild preeclampsia group （ P 〈 0.05 ）. The level of serum placental growth factor and heme oxygenase-1 in pregnant women with preeclampsia were negatively correlated with 24 h urinary protein and mean arterial pressure （ P 〈 0.05 ）. There was positive correlation between serum placental growth factor and serum heme oxygenase-1 in pregnant women with preeelampsia （P 〈0.05 ）. Conclusion Preeclampsia maternal serum placental growth factor and serum heme oxygenase-1 levels decrease. The serum placental growth factor and serum heme oxygenase-1 level are related to the severity of preeclampsia bot
作者
吴红莲
陈艳
黄志华
闫贵贞
夏伟兰
王双虎
WU Hong-lian;CHEN Yan;HUANG Zhi-hua(Department of Obstetrics and Gynecology,People＇s Hospital of Lishui City,Lishui,Zhejiang 323000,China)
出处
《中华全科医学》
2018年第11期1857-1859,共3页
Chinese Journal of General Practice
基金
2015年浙江省医药卫生一般研究计划(2015KYA230)
