摘要
目的:探讨N-乙酰半胱氨酸对慢阻肺患者血清C反应蛋白(C-reactiveprotein,CRP)、降钙素原(procalcitonin,PCT)表达水平及肺功能指标的影响。方法:通过随机抽样法从本院2017年4月~2018年4月收治的慢阻肺患者中选取82例,依据治疗方法差异分作两组,对照组41例患者施予常规治疗,实验组41例患者于常规治疗基础上予以N-乙酰半胱氨酸治疗,回顾性对比分析两组血清CRP、PCT水平及肺功能指标。结果:治疗后,实验组CRP(8.12±1.12)mg/L,PCT(1.78±0.22)μg/L,分别较对照组的CRP[(13.22±1.78)mg/L、PCT(3.85±0.27)μg/L]低,差异有统计学意义(P<0.05);治疗后,实验组用力肺活量、第1秒用力呼气容积、用力肺活量/第1秒用力呼气容积优于对照组,差异有统计学意义(P<0.05);治疗后,实验组圣乔治呼吸问卷评分较对照组低,差异有统计学意义(P<0.05)。结论:N-乙酰半胱氨酸可有效降低慢阻肺患者血清CRP、PCT表达水平,改善肺功能指标,进而提升其生活质量。
Objective： To evaluate the effect of N-acetylcysteine treatment on the levels of C-reactiveprotein （CRP）, procalcitonin （PCT） and pulmonary function indexes of the patientswith chronic obstructive pulmonary disease. Methods： A total of 82 cases of chronic obstructive pulmonary disease were selected in our hospital during April 2017 to April 2018, and were randomly divided into two groups according to the different treatment methods, 41 cases in control group with conventional treatment, and 41 cases in the experimental group with conventional treatment combined with N-acetylcysteine. The serum levels of CRP, PCT and pulmonary function were compared between the two groups. Results： After treatment, the levels of CRP [（8.12±1.12） mg/L] and PCT [（1.78±0.22） μg/L] in the experimental group were significantly lower than those of the control group [（13.22±1.78） mg/L and （3.85±0.27）μg/L] , respectively （ P 〈0.05）. The forced vital capacity, forced expiratory valume in 1 second （FEV1） and forced vital capacity/FEV1 in the experimental group were significantly superior to the control group （ P 〈0.05）. The scores of St. George＇s respiratory questionnaire in the experimental group were significantly lower than those in the control group （ P 〈0.05）. Conclusions： N-acetylcysteine treatment can effectively reduce the expression levels of CRP and PCT, improve pulmonary function, then improve the life quality of patients with chronic obstructive pulmonary disease.
作者
肖佛义
张庆
XIAO Fo-yi;ZHANG Qing(Ningde Hospital Affiliated to Fujian Medical University,Ningde Hospital Affiliated to Fujian Medical University,Ningde 352100,China)
出处
《海南医学院学报》
CAS
2018年第21期1881-1884,共4页
Journal of Hainan Medical University
基金
福建省卫生厅青年科研课题(2013-1-22)~~
