摘要
目的探讨血浆脑钠肽(BNP)联合心肌综合指数(Tei)评价酒精性肝硬化(AC)患者心功能的重要价值。方法选取2015年10月～2016年10月河北北方学院附属第一医院消化内科收治的73例酒精性肝硬化患者,根据肝功能分级标准(Child-Pugh)分为代偿期组(Child A组30例)、失代偿期组(Child B组23例,Child C组20例),另选取健康者25名作为对照组。用酶联免疫吸附试验(ELISA)检测各组的血浆BNP水平,并行彩色超声多普勒检测,统计Tei指数,进行组间比较。结果 Child B、Child C组血浆BNP水平均明显高于对照组和Child A组,而Child C组血浆BNP水平明显高于Child B组,差异均有统计学意义(P <0.05);Child B、Child C组左心室的Tei指数和等容舒张时间/射血时间(IRT/ET)值均明显高于Child A组和对照组,而Child C组则明显高于Child B组,差异均有高度统计学意义(P <0.01);各组右心室Tei指数和IRT/ET值差异无统计学意义(P> 0.05);酒精性肝硬化患者血浆BNP与左心室Tei指数呈显著正相关(r=0.618,P <0.01)。结论 Tei指数联合血浆BNP能准确评估酒精性肝硬化患者心功能的变化,为临床治疗提供科学参考。
Objective To investigate the important value of B-type natriuretic peptide （BNP） combined with Tei index for evaluating the cardiac function of patients with alcoholic cirrhosis. Methods A total of 73 patients with alcoholic cirrhosis treated in Department of Gastroenterology, the First Affiliated Hospital of Hebei North University from October 2015 to October 2016 were selected and they were divided into compensatory stage group （Child A group with 30 cases） and noncompensatory stage group （Child B group with 23 cases, Child C group with 20 cases） according to Child-Pugh liver function grading standard. Another 25 healthy volunteers were selected as control group. The plasma BNP level were detected by ELISA and were detected by colour ultrasound doppler. Statistics were used in analyzing the Tei index and it was compared among the groups. Results The plasma BNP level in Child B and Child C group were higher than those in Child A and control group, and the plasma BNP level in Child C group was higher than that in the control group, and there were significant differences （P 〈 0.05）. The Tei index of left ventricle and IRT/ET value in Child B and Child C group were higher than those in Child A and control group, and the Tei index of left ventricle and IRT/ET value in Child C group was higher than that in the control group, and all the differences were remarkably significant （P 〈 0.01）. While there was no difference in Tei index of right ventricle and IRT/ET value among all the groups （P 〉 0.05）. There was significantly positive correlation between plasma BNP and left ventricular Tei index in patients with alcoholic liver cirrhosis （r = 0.618, P 〈 0.01）. Conclusion Plasma BNP combined with Tei index could accurately evaluate the changes of cardiac function in patients with alcoholic cirrhosis and provide a scientific reference for clinical treatment.
作者
王立坤
张素梅
武雪亮
杨婕琳
杨瑞敏
韩朝
王义成
WANG Likun;ZHANG Sumei;WU Xueliang;YANG Jielin;YANG Ruimin;HAN Chao;WANG Yicheng(Department of Ultrasound,the First Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou 075000,China;Department of Ultrasound,the People′s Hospital of Xuanhua District,Hebei Province,Zhangjiakou 075100,China;Department of Vascular Surgery,the First Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou 075000,China;Department of Gastroenterology,the First Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou 075000,China)
出处
《中国医药导报》
CAS
2018年第32期125-128,134,共5页
China Medical Herald
基金
河北省张家口市科技局指令性计划项目(1621084D)
关键词
血浆脑钠肽
心肌综合指数
酒精性肝硬化
心功能
应用研究
B-type natriuretie peptide
Tel index
Alcoholic cirrhosis
Cardiac function
Application research
