摘要
通过对急性缺血性脑卒中患者进行磁共振弥散加权成像(DWI)检查和3个月的随访观察,探究磁共振弥散加权成像上新发生的卒中病灶位置与卒中后抑郁(PSD)之间的关系,期望能够对卒中患者能否发生卒中后抑郁方面提供帮助。方法:选择符合本实验入组标准的急性缺血性脑卒中患者70例。入院后完善磁共振弥散加权成像检查,并给予相应治疗,出院后对其进行随访,并对其进行汉密尔顿抑郁量表(HAMD)评分,观察并比较卒中后抑郁的发病率及其与磁共振弥散加权成像上新病灶的关系。结果:DWI上具有新病灶的急性缺血性卒中患者发病3个月内PSD发病率比较:多发脑梗死(75%)>额叶梗死(50.00%)>边缘系统梗死(21.43%)>基底节区梗死(12.5%),且各组患者间PSD发病率的比较具有统计学意义(p<0.05)。结论:发病3个月内PSD的发病率与DWI上新病灶之间具有相关性,且DWI上示多发脑梗死者PSD的发病率高于单个脑区梗死者, DWI检查对卒中后抑郁具有提示性。
To investigate the relationship between the location of new stroke lesions and post stroke depression（PSD） in patients with acute ischemic stroke by means of diffusion weighted imaging（DWI） and 3 months follow-up. Methods： 70 patients with acute ischemic stroke who met the criteria of this experiment were selected. Hanmierdun depression scale（HAMD） was used to evaluate the incidence of post stroke depression and its relationship with new lesions in diffusion-weighted MRI. Results： The comparison of the incidence of PSD of acute ischemic stroke patients whose responsibility lesions was showed on DWI lesions in three months ：multiple cerebral infarction（75%）〉frontal lobe infarction（50. 00%）〉limbic system infarction （21.43%）〉basal ganglia infarction（12.5%）,and the incidence of PSD has significant difference （p 〈0.05）. Conclusion： The incidence of PSD was correlated with the new lesions on DWI in 3 months, and the incidence of PSD was higher than that of single cerebral infarction on DWI.
