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左心室肥厚对合并高血压阵发性心房颤动患者射频消融术后复发的影响 被引量:10

Electrocardiographic left ventricular hypertrophy predicts recurrence of atrial arrhythmias after catheter ablation of paroxysmal atrial fibrillation with hypertension
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摘要 目的本研究旨在探讨左心室肥厚伴或不伴劳损对合并高血压阵发性心房颤动(房颤)患者射频消融术后复发的影响。方法连续入选2007年1月至2014年5月于北京安贞医院第一次接受导管射频消融术的280例抗心律失常药物治疗无效或不能耐受并同意手术治疗的合并高血压的症状性阵发性房颤患者。根据患者术前窦性心律心电图,依据左心室肥厚Romhilt-Estes评分系统及是否伴有ST-T劳损性改变,将患者共分为3组[1组(正常组,140例);2组(左心室肥厚不伴劳损组,114例);3组(左心室肥厚伴劳损组,26例)],手术方式均为三维电解剖标测系统指导下行左心房重建及环肺静脉电隔离术,术后由随访人员定期随访患者主诉、心电图、24 h动态心电图、超声心动图等。结果截至2017年1月,平均手术1.19±0.46次,中位随访42(四分位数24~66)个月,169例维持窦性心律,104例复发,失访7例;1组患者窦性心律维持率明显高于2组及3组患者,分别为74.3%(1组)、48.2%(2组)、38.5%(3组),差异有统计学意义(P〈0.001)。单因素回归分析中,血栓栓塞评分(CHA2DS2-VASc积分),心电图异常包括左心室肥厚及左心室肥厚伴劳损,左心房内径以及脑钠肽是患者复发的危险因素;在多因素分析中,仅有心电图异常包括左心室肥厚及左心室肥厚伴劳损是合并高血压阵发性房颤患者射频消融术后复发的独立危险因素(HR=2.103,95% CI 1.231~3.590;HR=2.621,95% CI 1.238~5.550)。结论心电图异常左心室肥厚伴或不伴劳损是合并高血压阵发性房颤患者射频消融术后复发的独立危险因素。 ObjectiveTo investigate whether left ventricular hypertrophy (LVH) or LVH with ST-T strain on electrocardiogram (ECG) can predict arrhythmia recurrence after radiofrequency catheter ablation (RFCA) in paroxysmal atrial fibrillation (PAF) patients with hypertension.MethodsFrom January 2007 to May 2014, 280 PAF patients with hypertension undergoing RFCA in Beijing Anzhen Hospital were consecutively enrolled, and clustered into 3 groups based on the preoperational ECG findings: Non-LVH (140 patients) , ECG LVH (114 patients) , ECG LVH with ST-T Strain (26 patients) . The Romhilt-Estes point score≥5 points were defined as LVH. LVH with strain was defined as LVH and ST-segment depression≥0.1 mV with inverted asymmetric T wave≥0.1 mV opposite the QRS axis in the lateral leads in a resting ECG.ResultsAfter 42 (interquartile range, 24.0-66.0 months) months follow-up period post 1.19±0.46 times of RFCA procedures, 169 patients (61.9%) maintained sinus rhythm without using antiarrhythmic drugs, 104 (74.3%) in the non-LVH group, 55 (48.2%) in the LVH group, 10 (38.5%) in the LVH with strain group (P〈0.001) . Multivariate analysis indicated ECG abnormalities including LVH and LVH with strain to be independent risk factors for recurrence after adjusting for confounding factors (HR=2.103, 95% CI 1.231-3.590; HR=2.621, 95% CI 1.238-5.550; respectively) .ConclusionThe ECG abnormalities including LVH and LVH with strain were strong and independent predictors of recurrence present of in PAF patients with hypertension following RFCA.
作者 王璐 李松南 董建增 喻荣辉 龙德勇 汤日波 蒋晨曦 桑才华 刘念 白融 杜昕 马长生 Wang Lu;Li Songnan;Dong Jianzeng;Yu Ronghui;Long Deyong;Tang Ribo;Jiang Chenxi;Sang Caihua;Liu Nian;Bai Rong;Du Xin;Ma Changsheng(Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,National Clinical Research Centre for Cardiovascular Diseases,Beifing Institute of Heart Lung and Blood Vessel Disease,100029,China)
出处 《中华心律失常学杂志》 2018年第5期412-418,共7页 Chinese Journal of Cardiac Arrhythmias
基金 国家自然科学基金(81370291) 首都卫生发展科研专项(2014-1-2061)
关键词 心房颤动 左心室肥厚 导管消融 Atrial fibrillation Left ventricular hypertrophy Radiofrequency catheter ablation
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