摘要
调节性非编码RNA(non-coding RNA, ncRNA)是近年来研究的热点之一,主要包括微小RNA(microRNA, miRNA)和长链非编码RNA(long non-coding RNA, lncRNA)等。lncRNA是一类长度超过200个核苷酸的功能性非编码RNA,而mi RNA则是一类广泛分布的约含20个核苷酸的短链非编码RNA,它们在细胞的生长、增殖、分化等方面都起着关键的调节作用。同时,相关研究也表明, lncRNA和miRNA之间存在复杂的调节关系,在很多疾病尤其是癌症的发生和发展中起着重要的作用。该文就lncRNA和miRNA之间存在的调节关系以及ceRNA调节网络的研究进展作一综述。
Regulatory non-coding RNA （ncRNA） is one of the hot spots to research in recent years. It mainly includes microRNA （miRNA） and long non-coding RNA （lncRNA）. LncRNA is a kind of functional non-coding RNA with more than 200 nucleotides in length, while miRNA is a kind of short chains of non-coding RNA about 20 nucleotides that widely distributed in genome. They both play key regulatory roles in cell growth, proliferation and differentiation. At the same time, relevant studies have shown that there are complex regulatory relationships be- tween IncRNA and miRNA, which play important roles in the occurrence and development of many diseases, especially cancer. This review mainly focused on the research progress of the interaction between lncRNA and miRNA and ceRNA network.
作者
沈钲杰
朱银银
沈凡含
阿不力米提.木合塔尔
廖奇
Shen Zhengjie;Zhu Yinyin;Shen Fanhan;Ablimt.Muhtar;Liao Qi(Department ofPreventive Medicine,Medicine School of Ningbo University,Ningbo 315221,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2018年第10期1774-1780,共7页
Chinese Journal of Cell Biology
基金
宁波市自然科学基金(批准号:2017A610154)
宁波环境有害因素的预防与控制科技创新团队(批准号:2016C51001)
宁波大学王宽诚教育基金资助的课题~~
