摘要
目的:探讨补肾疏肝方治疗肝肾不足型帕金森病(PD)伴发轻中度抑郁障碍患者的临床疗效。方法:将7 8例肝肾不足型PD伴发轻中度抑郁障碍患者随机分为观察组和对照组各39例。对照组给予卡左双多巴控释片和唯他停盐酸舍曲林片对症治疗,观察组在对照组基础上给予补肾疏肝方治疗。治疗9月后,比较2组治疗前后PD统一评分量表(UPDRS)评分、Hamilton抑郁量表(HAMD)评分、PD生活质量量表(PDQ-39)评分、中医证候评分,评估2组轻中度抑郁构成比、临床疗效和不良反应发生率。结果:治疗前,2组UPDRS、HAMD、PDQ-39、中医证候评分比较无差异(P>0.05);治疗后,2组UPDRS、HAMD、PDQ-39、中医证候评分均较治疗前下降(P<0.05),观察组各项评分较对照组下降更明显(P<0.05)。治疗后,轻中度抑郁构成比观察组为7 1.7 9%,对照组为9 4.87%,2组比较,差异有统计学意义(P<0.05);总有效率观察组为9 2.31%,对照组为7 4.36%,2组比较,差异有统计学意义(P<0.05);不良反应发生率观察组为12.82%,对照组为15.38%,2组比较,差异无统计学意义(P>0.05)。结论:补肾疏肝方能够显著改善肝肾不足型PD伴发轻中度抑郁障碍患者精神、运动、日常生活等症状,抗抑郁效果明显,能显著提高患者生活质量,有效缓解肝肾不足型患者中医症状,临床疗效佳。
Objective： To observe the clinical effect of Bushen Shugan prescription for patients with Parkinson＇s disease（PD）accompanying mild to moderate depressive disorder of liver-kidney deficiency type. Methods： Divided 78 cases of PD patients accompnying mild to moderate depressive disorder of liver-kidney deficiency type into the observation group and the control group randomly, 39 cases in each group. The control group was given carbidopa and levodopa controlled-release tablets and Weitating sertraline hydrochloride tablets for treatment, the observation group was additionally given Bushen Shugan prescription for treatment.After 9 months of treatment, compared scores of the unified Parkinson＇s disease rating scale（UPDRS）, Hamilton depression scale（HAMD）, Parkinson＇s disease questionnaire（PDQ-39） and Chinese medicine syndrome of both groups before and after treatment, and evaluated the constituent ratio of mild to moderate depression,the clinical effect and the incidence of adverse reactions of both groups.Results：Before treatment,there were no significant differences being found in the scores of UPDRS,HAMD,PDQ-39 and Chinese medicine syndrome of both groups（P〈0.05）, after treatment, the scores of UPDRS, HAMD, PDQ-39 and Chinese medicine syndrome of both groups were lower than those before treatment（P〈0.05）,and each score in the observation group was decreased more significantly than that in the control group（P〈0.05）. After treatment,the constituent ratio of mild to moderate depression was 71.79%in the observation group and 94.87% in the control group,difference being significant（P〈0.05）;the total effective rate was 92.31%in the observation group and 74.36% in the control group,difference being significant（P〈0.05）;the incidence of adverse reactions was12.82% in the observation group and 15.38% in the control group,difference being insignificant（P〈0.05）. Conclusion：Bushen Shugan prescription can significantly improve symptoms such as mentality,motion and
出处
《新中医》
CAS
2018年第8期74-77,共4页
New Chinese Medicine
