摘要
目的探讨参芎葡萄糖注射液联合奥拉西坦注射液治疗脑梗死的临床疗效。方法选取2016年5月—2017年12月宝鸡市第三人民医院收治的急性脑梗死患者110例作为研究对象,根据随机区组设计法将患者分为对照组(55例)和治疗组(55例)。对照组静脉滴注奥拉西坦注射液,将4 g奥拉西坦与250 mL生理盐水混合均匀,1次/d。治疗组在对照组治疗的基础上静脉滴注参芎葡萄糖注射液,100 mL/次,1次/d。两组患者均连续治疗21 d。观察两组患者的临床疗效,同时比较治疗前后两组的认知功能和生活能力、血液流变学指标、血清因子指标和血管内皮功能指标。结果治疗后,对照组和治疗组的总有效率分别为78.2%、94.5%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分显著降低,蒙特利尔认知评估量表(Mo CA)、Barthel评分均显著升高,同组治疗前后比较差异具有统计学意义(P<0.05)。且治疗后,治疗组NIHSS评分显著低于对照组,Mo CA、Barthel评分显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组全血黏度(BV)、血浆黏度(SV)、血小板聚集率(PAR)、纤维蛋白原(FIB)和红细胞压积(HCT)均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05)。且治疗后,治疗组血液流变学指标均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清白细胞介素-6(IL-6)、同型半胱氨酸(Hcy)、S100β蛋白(S100β)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05)。且治疗后,治疗组血清因子水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。且治疗后,两组血清一氧化氮(NO)水平显著升高,内皮素-1(ET-1)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05)。且治疗后,治疗组血管内皮功能因子水平显著优于对照组,两组比较差异�
Objective To investigate the clinical effect of Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection combined with Oxiracetam Injection in treatment of cerebral infarction. Methods Patients（110 cases） with cerebral infarction in the Third People’s Hospital of Baoji City from May 2016 to December 2017 were randomly divided into control（55 cases） and treatment（55 cases） groups. Patients in the control group were iv administered with Oxiracetam Injection, and 4 g Oxiracetam Injection was added to 250 mL normal saline, once daily. Patients in the treatment group were iv administered with Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection on the basis of the control group, 100 mL/time, once daily. Patients in two groups were treated for 21 d. After treatment, the clinical efficacies were evaluated, and cognitive function, life ability, hemorheological indexes, serum indexes, and vascular endothelial function indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.2% and 94.5%, respectively, and there was difference between two groups（P 〈 0.05）. After treatment, NIHSS score was significantly decreased in two groups, but MoCA and Barthel scores were significantly increased, and there were differences in the same group（P 〈 0.05）. After treatment, NIHSS score in the treatment group were lower than those in the control group, but MoCA and Barthel scores were higher than those in the control group, and there were differences between two groups（P 〈 0.05）. After treatment, the BV, SV, PAR, FIB, and HCT in two groups were significantly decreased, and the difference was statistically significant in the same group（P 〈 0.05）. After treatment, the hemorheological indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P 〈 0.05）. After treatment, the levels of serum IL-6,
作者
卢建国
张珍莉
王瑾
李文忠
LU Jian-guo;ZHANG Zhen-li;WANG Jin;LI Wen-zhong(Department of Neurology,the Third People＇s Hospital of Baoji City,Baoji 721004,China)
出处
《现代药物与临床》
CAS
2018年第10期2505-2510,共6页
Drugs & Clinic
关键词
参芎葡萄糖注射液
奥拉西坦注射液
脑梗死
认知功能
生活能力
血液流变学
血清因子
内皮功能因子
Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection
Oxiracetam Injection
cerebral infarction
cognitive function
life ability
serum index
hemorheological index
endothelial function index
