摘要
目的:采用光释光法建立牛黄清胃丸^(60)Co-γ辐照的检测方法,以未经辐照的对照制剂为参考,评价样品辐照情况。方法:参照欧盟标准(EN)13751:2002,利用SURRC PPSL辐照食品筛查系统,无需前处理,直接检测样品辐照情况。结果:测定值可以反映样品是否经过辐照,阴性对照无干扰。18个厂家的49批次样品PSL值在223~163 756,可初步推测部分被测样品经过^(60)Co-γ辐照灭菌处理。结论:所建方法操作简便、快速、经济,可为牛黄清胃丸的质量控制和安全用药提供参考。
Objective： To establish a photostimulated luminescence （PSL） method for the detection of ^60Co-γ irradiated Niuhuang Qingwei pills, and evaluate the irradiation situation of samples by using the irradiation-free pills as reference. Methods： Based on European standard of EN 13751：2002, the irradiation condition of samples was detected directly without pretreatment using the SURRC （PPSL） system as the analyzer. Results： The measured values could reflect the irradiation of samples without interference from the negative sample. The PSL values of 49 bathes of samples from 18 manufacturers were within 223-163 756, which indicted that all the in-vestigated samples were sterilized by ^60Co-γ irradiation. Conclusion： The proposed method is simple, fast and economic, which prorides reference for the quality control and safe use of Niuhuang Qingwei pills.
作者
查祎凡
聂黎行
王赵
于健东
戴忠
马双成
Zha Yifan;Nie Lixing;Wang Zhao;Yu Jiandong;Dai Zhong;Ma Shuangcheng(National Institutes for Food and Drug Control,Beijing 100050,China;China Pharmaceutical University)
出处
《中国药师》
CAS
2018年第11期1898-1900,共3页
China Pharmacist
基金
国家自然科学基金项目(编号:81303194)
中国食品药品检定研究院学科带头人培养基金项目(编号:2017X1)
关键词
牛黄清胃丸
^60Co-γ射线
辐照
光释光法
对照制剂
Niuhuang Qingwei pills
^60Co-γ irradiation
Radiation exposure
Luminescence method
Reference drug
