摘要
目的手足口病是临床上常见的传染性疾病,严重影响患儿身心健康。本研究分析凤城市手足口病患儿的病原学检测及临床特点,为早期发现、诊断手足口病及提高患儿临床预后提供依据。方法选择2016-01-10-2017-07-10凤城市监测的342例手足口病患儿作为研究对象,采用荧光PCR法对该地区的手足口病患儿检测肠道病毒71型、柯萨奇A16型、其他肠道病毒类型,分析和比较手足口病患儿肠道病毒分型情况,病原学与临床特点的关系。结果 342例手足口病患儿病原体检测发现,肠道病毒71型阳性109例(31.87%),柯萨奇A16型阳性51例(14.91%),其他肠道病毒类型阳性72例(21.05%),未检测出110例(32.16%)。肠道病毒71型手足口病患儿呕吐发生率为94.50%,柯萨奇A16型手足口病患儿呕吐发生率为82.35%,其他肠道病毒型手足口病患儿呕吐发生率为70.83%,三者比较差异有统计学意义,χ2=5.510,P=0.018;肠道病毒71型手足口病患儿咳嗽发生率为17.43%,柯萨奇A16型手足口病患儿咳嗽发生率为33.33%,其他肠道病毒型手足口病患儿咳嗽发生率为45.83%,三者比较差异有统计学意义,χ2=7.864,P=0.005。结论肠道病毒71型、柯萨奇A16型和其他肠道病毒类型是手足口病最为常见的致病类型,呕吐和咳嗽发生率存在一定的差异,临床上应加强上述病原体的鉴别诊断及临床特点分析。
OBJECTIVE The hand-foot-and-mouth disease is a common infectious disease in clinical practice,which seriously affects children＇s physical and mental health.This study analyzed the pathogeny and clinical characteristics of the children with hand-foot-and-mouth disease in Fengcheng,and provided a basis for the early detection,diagnosis of handfoot-and-mouth disease and the improvement of the clinical prognosis of children.METHODS A total of 342 children with hand-foot-and-mouth disease from January 10,2016 to July 10,2017 in Fengcheng city were chosen as the research object.The type of enterovirus 71,Coxsackie A16 and other enteroviruses were detected by fluorescence PCR in children with hand-foot-and-mouth disease in this area.The relationship between the enterovirus typing and the clinical characteristics of the children with hand-foot-and-mouth disease was analyzed and compared.RESULTS Detection of pathogens in 342 cases of hand-foot-and-mouth disease,the number of positive cases of enterovirus 71 was 109 cases（31.87%）,51 cases（14.91%）of Coxsackie A16 positive cases,other enterovirus types were positive in 72 cases（21.05%）,110 cases（32.16%）were not detected.The incidences of vomiting in children with enterovirus 71,Coxsackie A16 and other enterovirus type respectively were 94.50%,82.35% and 70.83%,with statistically significant difference between them（χ^2=5.510,P=0.018）.Similarly,the incidences of cough in children with these enterovirus respectively were 17.43%,33.33% and 45.83%,also with the statistically significant difference between them（χ^2=7.864,P=0.005）.CONCLUSION Enterovirus 71,Coxsackie A16 and other enterovirus types are the most common pathogenic types of hand-footand-mouth disease.There are certain differences in the incidence of vomiting and cough.The differential diagnosis and clinical characteristics of these pathogens should be strengthened in clinical practice.
作者
袁清泉
YUAN Qing-quan(Fengcheng Center for Disease Control and Prevention,Fengcheng 118100,P.R.China)
出处
《社区医学杂志》
2018年第13期1072-1074,共3页
Journal Of Community Medicine
关键词
凤城市
手足口病
病原学检测
临床特点
Fengcheng city
hand foot-and mouth disease
pathogeny detection
clinical characteristics
