摘要
胆囊结石的治疗以手术、内镜治疗为主,近年大量研究提出了药物防治胆囊结石的新观点、新思路。总结了目前已进入临床研究的胆汁酸类药物、他汀类药物、依泽替米贝以及作用于胆固醇和胆汁酸稳态相关特定核受体的药物在防治胆囊结石中的效用和安全性,并指出可能具有胆囊结石防治意义的药物、分子位点,为个体化胆囊结石药物防治策略制订和研究提供依据。
The treatment of gallstones mainly relies on surgery and endoscopy,and in recent years,a large number of studies have proposednew ideas and thoughts for drugs in the prevention and treatment of gallstones. This article summarizes the efficacy and safety of bile aciddrugs,statins,ezetimibe,and drugs acting on specific nuclear receptors involved in cholesterol and bile acid homeostasis,which have entered the clinical trial stage,in preventing and treating gallstones. It is pointed out that certain drugs and molecular sites may have some clinical effects in the prevention and treatment of gallstones,which provides a basis for developing individualized strategies for the prevention andtreatment of gallstones with drugs.
作者
徐敬昌
叶辉
王大松
XU Jingchang;YE Hui;WANG Dasong(Department of Biliary Surgery,West China Hospital of Sichuan University,Chengdu 610041,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2018年第11期2453-2457,共5页
Journal of Clinical Hepatology
基金
公益性行业科研专项(201502014)
关键词
胆囊结石病
药物疗法
综述
cholecystolithiasis
drug therapy
review
